Trias Kusuma Sari, Irwanto Irwanto, Risa Etika, Mahendra Tri Arif Sampurna, Ni Made Mertaniasih

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C-reactive protein (CRP) is an acute-phase reactant protein that is primarily induced by the IL-6 action during the acute phase of an inflammatory or infectious process. Bacterial infection is a potent stimulus, leading to a rapid elevation of CRP levels within hours while the CBC and symptom are often misleading and/or absent. American Academy of paediatrics (AAP) is recommended routine blood examination test Complete Blood Count (CBC), C-reactive protein (CRP), and blood culture along with empirical antibiotic in neonates with early onset sepsis risk (EOS) risk even asymptomatic. Previous study is showed there were no correlation of CRP and EOS risk. The aim of this study is to evaluate the CRP and CBC profile in neonate with risk of EOS.  Methods of this study is using the sepsis risk calculator (SRC) to calculate the probability of neonatal early onset sepsis (EOS) based on maternal risk and infant’s clinical presentation. Neonates with ≥34 weeks of gestation who were started on antibiotic treatment after laboratory examination and blo odculture were taken. EOS risk estimation were compared including CRP, leukocyte, and thrombocyte count. ANOVA applied to distinguished laboratory examination between stratified risk groups. The result is showed using 82 subjects who met the inclusion and exclusion criterias, EOS risk level was stratified into green, yellow, and red group. The p value of CRP level, platelets, white blood cell were 0.35,0.54 and 0.48 where p value was considered as significant if < 0.5. The conclusion of this study is there were no correlation of CRP level and EOS risk



Sepsis risk calculator, infection parameter, risk of early onset sepsis, C-reactive protein, Complete Blood Count

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Tita, a. T. dan Andrew W. Diagnosis and management of clinical chorioamnionitis. Clin perinatol 2010; 37: 339-54.

Puopolo KM, Draper D, Wi S, Newman TB, Zupancic J, Lieberman E, et al. Estimating the probability of neonatal early-onset infection on the basis of maternal risk factors. Pediatrics;2011. VOL 128 p. 1155-63.

Polin RA, Papile L-A, Baley JE, et al. Management of neonates with suspected or proven early-onset bacterial sepsis. Pediatrics; 2012.p. 129

Fanaro, s., Chierici, r., dan Guerrini, p, 2003. Intestinal microflora in early infancy: composition and development. Acta paediatr suppl, 91: p. 48-55.

Escobar, g. J., Puopolo, k. M., dan Wi, s, 2014. Stratification of risk of early-onset sepsis in newborns ≥ 34 weeks' gestation. Pediatrics; vol 133 p. 30-6.

Kerste, M., Corver, J., Sonnevelt, M. C., dkk, 2016. Application of sepsis calculator in newborns with suspected infection. J matern fetal neonatal med; vol 29 p. 3860-5.

Manzoni P, M. M., Galletto P, Gastaldo L, Gallo E, Agriesti G, dan Farina D, 2009. Is thrombocytopenia suggestive of organism-specific response in neonatal sepsis? Pediatr. Int.; vol 51 p. 206–10.

Kamble R dan Rajesh Ovhal R, 2015. Bacteriological profile of neonatal septicemia.Int.J.Curr.Microbiol.App.Sci; vol 2 p. 172-182

Meem, M., Modak, J. K., Mortuza, R., Morshed, M., Islam, M. S. dan Saha, S. K, 2011. Biomarkers for diagnosis of neonatal infections: a systematic analysis of their potential as a point-of-care diagnostics. J Glob Health; vol 1 p. 201-9.

Hofer N, Zacharias E, Müller W, Resch B. An Update on the Use of C-Reactive Protein in Early-Onset Neonatal Sepsis: Current Insights and New Tasks. Neonatology 2012; vol 102 p. 25–36

Benitz, w. E., Han, m. Y., Madan, A. dan Ramachandra, P, 1998. Serial serum c-reactive protein levels in the diagnosis of neonatal infection. Pediatrics; vol 102 p. 41.

Nora H, Eva Z, Wilhelm M, dan Bernhard R, 2012. An Update on the Use of C-Reactive Protein in Early-Onset Neonatal Sepsis: Current Insights and New Tasks. Neonatol; vol 102 p 25–36.

Joseph B, Cantey, dan Stephen Baird, 2017. Ending the Culture of Culture-Negative Sepsis in the Neonatal ICU. Pediatrics, 140: 1-5

Buttery J, 2002. Blood cultures in newborns and children: optimising on everyday test. Arch Dis Child Fetal Neonatal, 87: 25-8.

Connell Tg, R. M., Cowley D, Buttery Jp, dan Curtis N, 2007. How reliable is a negative blood culture result? Volume of blood submitted for culture in routine practice in a children’s hospital. Pediatrics, 119:891–6.

Anderson bl, Simons km, dan Wiesenfeld Hc, 2007. Untreated asymptomatic group b streptococcal bacteriuria early in pregnancy and chorioamnionitis at delivery. Am j obstet gynecol, 6: 524–5.

Alonso T dan Theresa O, 2015. Challenges in the diagnosis and management of neonatal sepsis. J Trop Pediatr, 61:1-13

Somaia E, Mervat E, Reem H, Doaa A, Qassem, dan Gameel, 2016. The Role of 16S rRNA Gene Sequencing in Confirmation of Suspected Neonatal Sepsis. J Trop Pediatr, 62:75–80

Simonsen, K. A., Anderson-Berry, A. L., Delair, S. F. dan Davies, H. D, 2014. Early-onset neonatal sepsis. Clin microbiol rev, 27: 21-47.

Rasmussen, 2015. Aerococcus: an increasingly acknowledged human pathogen. Clin Microbiol Infect, 22: 22-7


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