Prevalence of Methicillin-resistant Staphylococcus aureus (MRSA) Carrier in Hemodialysis Patients at Dr. Soetomo Academic General Hospital
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Chronic kidney disease (CKD) is now a global epidemic, and the prevalence is increasing worldwide. Hemodialysis is one of the ways to treat by kidney function replacement. Infection is the number two cause of death in patients with hemodialysis (HD). Methicillin-resistant Staphylococcus aureus (MRSA) is a common cause of bacteriemia in patients with dialysis. The epidemiological data of MRSA carriers in CKD in Indonesia are still scarce. This study was to determine the prevalence of MRSA carriers in patients at The Kidney and Hypertension Outpatient-clinic and Hemodialysis Installation at Dr. Soetomo Academic General Hospital, Surabaya Indonesia. The study design was descriptive-analytic with a cross- sectional study design. Sampling was collected consecutively. Data on the general characteristics of the research subjects will be analyzed using a Chi-Squared test. There were 150 CKD stage five patients included in this study, the number of patients has MRSA carrier were 6 (4%), among them, subjects underwent HD MRSA carrier were 2 subjects(2.7%), while for non-HD patients with MRSA were 4 subjects (5.3 %). There were no significant differences in MRSA carriers between HD and non HD groups (p=0.404). Comorbid factors that accompany MRSA carriers are diabetes mellitus, hypertension, kidney stones, gout, and systemic lupus erythematosus (SLE). This study found, there were no significant differences in the incidence of MRSA carriers in stage five CKD non HD or HD groups. MRSA colonization exists in stage five CKD sufferers, so awareness of MRSA colonization
Stevens LA, Coresh J & Selvin E, 2009. Prevalence of Chronic Kidney Disease In the United States. JAMA, 298, pp:2038-2047
Huang YH, Tseng SP, Hu JM, Tsai JC, Hsueh PR, Teng LJ. 2007. Clonal Spread of SSCmec type IV methicillin resistant Staphylococcus aureus between community and hospital. ClinMicrobiol Infect; 13(7):717-24.
Stone JCV, 1994. Hemodialysis apparatus. In (JT Daugirdas, TS Ing, eds). Handbook of dialysis, 2nd edition. London: Little, Brown and Company, pp:30-52
Chen CC, Chen CL, Fang HC, Lee PT, Chang TY, Chou KJ, Chung HM. 2005. The risk factors of Staphylococcus aureus bacteremia related mortality among patients undergoing hemodialysis. Acta Nephrologica 18: 162-166.
Levi J, Morgan J & Brown E, 2004 A Practical Guide to Dialysis and How to Manage End Stage Renal Failure. Oxford Handbook 2nd Ed
Datta R, Huang SS, 2008. Risk of Infection and Death due to Methicillin-Resistant Staphylococcus aureus in Long-Term Carriers. Clinical Infection Disease 47:176-81
Zacharioudakis IM, Zervou FN, Ziakas PD, and Mylonakis E. 2014. Meta-Analysis of Methicillin-Resistant Staphylococcus aureus Colonization and Risk of Infection in Dialysis Patients. J Am Soc Nephrol. 25(9): 2131-2141.
Agata EMCD. 2018. Addressing the Problem of Multidrug-Resistant Organisms in DialysisClin J Am Soc Nephrol. 6; 13(4): 666–668. doi: 10.2215/CJN.13781217
Vanholder R, Schepers E, Meert N & Lameire N, 2006. What is uremia? Retention vs. Oxidation Blood Purif. 2006;24, pp:33-38
Dougirdas JT, Blake PG & Ing TS, 2015. Infection. Handbook of Dialysis 5th Ed. A Lippincott William's & Wilkins handbook. Wolters Kluwer pp:615-663
Chatterjee A, Rai S, Guddattu V, Mukhopadhyay C, and Saravu K. 2018. Is methicillin-resistant Staphylococcus Aureus infection associated with higher mortality and morbidity in hospitalized patients? A cohort study of 551 patients from South Western India Risk Manag Healthc Policy. 11: 243–250.doi: 10.2147/RMHP.S176517
Tiemersma EW, Bronzwaer SL, Lyytikäinen O. 2004. European antimicrobial resistance surveillance system participants. Methicillin-resistant Staphylococcus aureus in Europe, 1999–2002. Emerg Infect Dis2004; 10: 1627–1634.
Nahimana I, Francioli P, Blanc DS. 2006. Evaluation of Three chromogenic media (MRSA-ID, MRSA-Select, and Chromagar-MRSA) and ORSAB for Surveillance cultures of methicillin-resistant Staphylococcus aureus. Clin Microbiol Infect.; 12(12):1168-74.
Stoakes L, Reyes R, Daniel J, Lennox G, John MA, Lannigan R, Hussain Z. 2006. Prospective comparison of a new chromogenic medium, MRSASelect, to CHROMagar MRSA and mannitol-salt medium supplemented with oxacillin or cefoxitin for detection of methicillin-resistant Staphylococcus aureus.J Clin Microbiol 44(2):637-9.
Kuntaman K., Hadi U., Setiawan F., Koendori EB., Rusli M., Santosaningsih D & Verbrugh HA. 2016. Prevalence of Methicillin-Resistant Staphylococcus aureus from Nose and Throat of Patients on Admission to Medical Wards of Dr. Soetomo Hospital, Surabaya. Indonesia. Southeast Asian Journal of Tropical Medicine and Public Health 2016, 47 (1), pp:66-70.
Wang CY, Wu VC, Wang WJ, Lin YF, Lin YH, Chen YM, Su CT, Wang JY, Wu KD & Hsueh PR, 2012. Risk factors for nasal carriage of methicillin-resistant Staphylococcus aureus among patients with end-stage renal disease in Taiwan. Journal of the Formosan Medical Association (2012) 111, 14-18
Celik G, Gulkan A, Dikici N & Gulcan E, 2011, Prevalence of Nasal Staphylococcus aureus Carriage in the Patients Undergoing Hemodialysis and Evaluation of Risk Factors and Laboratory Parameters. Pp:494-498
Kang YC, Tai WC, Yu CC, Kang YH, and Huang YC. (2012). Methicillin-resistant Staphylococcus aureus nasal carriage among patients receiving hemodialysis in Taiwan: prevalence rate, molecular characterization, and de-colonization. BMC Infectious Diseases 12:284. Available in: http://www.biomedcentral.com/1471-2334/12/284. Accessed 5th. Dec. 2019
Lai CF, Liao CH, Pai MF, Chu FY, Hsu SP, Chen HY, Yang JY, Chiu YL, Peng YS, Chang SC, Hung KY, Tsai TJ, Wu KD. 2011. Nasal carriage of methicillin-resistant Staphylococcus aureus is associated with higher all-cause mortality in hemodialysis patients. Clin J Am Soc Nephrol. 6(1):167-74 DOI: 10.2215/CJN.06270710
Yeoh LY, and Tan FL, Willis GC & Ooi ST., 2014. Methicillin-resistant Staphylococcus aureus carriage in hospitalized chronic hemodialysis patients and its predisposing factors. Hemodialysis International 2014, pp:142-147
Saxena AK, Panhotra BR, Venkateshappa CK, Sundaram DS, Naguib M, Uzzaman, W & Al Mulhim K., 2002. The Impact of Nasal Carriage of Methicillin-Resistant Staphylococcus aureus and Methicillin-Susceptible Staphylococcus aureus (MRSA & MSSA) On Vascular Access-related septicemia among patients with type-II Diabetes on Dialysis. Renal Failure Vol. 24, No 6, pp:763-777.
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