Risk Factors of Neonatal Sepsis: A Preliminary Study in Dr. Soetomo Hospital

Martono Tri Utomo

= http://dx.doi.org/10.20473/ijtid.v1i1.3718
Abstract views = 1619 times | downloads = 1320 times


The risk factors of developing neonatal sepsis could be caused by maternal and neonatal risk factors. Objective to determine the characteristics and risk factors for neonatal sepsis. Study design was case control study. The data of neonates were taken from the medical record. Neonates who were admitted in neonatal care unit of Dr. Soetomo hospital were included at January 2010 to February 2010, and divided into 2 groups, one group was sepsis cases and other group was non sepsis cases as a control. The risk factors that associated with sepsis were studied. Chi square and logistic regression analysis were used to analyze the data. 97 patients were included
and 31were sepsis cases and non sepsis case were 66. The risk factors that significantly cause sepsis are low birth weight (p=0.001 OR 2.75, 95% CI 1.454–5.200) , prematurity (p=0.000, OR 4.073, 95% CI 2.180–7.609), meconeal amniotic fluid (p=0.029, OR 2.535,
95% CI 1.225–5.245) and C-section (p=0.032, OR 1.895, 95% CI 1.087–3.303). The significant risk factors of the neonatal sepsis are
low birth weight, prematurity, meconeal amniotic fluid, and caesarian section


risk factors, neonatal sepsis

Full Text:



Gomella T, Cunningham MD, Eyal FG. Sepsis. In: Gomella T,

Cunningham MD, Eyal FG., editor. Neonatology management,

procedures, on-call problems, diseases and drugs. 6th ed. New York: The Mc Graw-Hill, Co, Inc; 2009. p. 665–72.

Klein JO, Marcy SM. Bacterial sepsis and meningitis. In: Remington J, Klein JO, editor. Infectious diseases of the fetus and newborn infant. 3rd ed. Philadelphia: W.B. Saunders Co; 1990. p. 610–25.

Vergnano S, Sharland M, Kazembe P, Mwansambo C, Heath PT. Neonatal sepsis: an international perspective. Arch Dis Child Fetal Neonatal Ed. 2005;90:F220–4.

Yu V, Monintja H. Infeksi sistemik pada neonatus. In: Yu V, Monintja H, editor. Beberapa masalah perawatan intensif neonatus. 1st ed. Jakarta: Balai penerbit FK UI; 1997. p. 217–30.

Rohsiswatmo R. Kontroversi diagnosis sepsis neonatorum. In: Hegar B, Trihono PP, Ifran EB, editor. Update in neonatal infection. Jakarta: Departemen Ilmu Kesehatan Anak FKUI-RSCM; 2005. p. 32–43.

Rahman T, Utomo MT, Etika R, Indarso F, Harianto A, Damanik SM. Sepsis neonatorum di RSU Dr Soetomo Surabaya 2006. In: Sadjimin T, Juffrie M, Julia M, Wibowo T, editor. PIT IKA III IDAI; 2007; Yogyakarta: Percetakan KITA; 2007. p. 532.

Puopolo K. Bacterial and fungal infections. In: Cloherty J, Eichenwald EC, Stark AR, editor. Manual of neonatal care. 5th ed. Philadelphia: Lippincott William & Wilkins; 2008. p. 275–300.

Haque KN. Definition of blood stream infection in the newborn.

Pediatr Crit Care Med. 2005;6:S45–9.

McCracken G, Schleonka R, Freij BJ,. Bacterial and viral infections of the newborn. In: McDonald M, Mullen MD, Seshia MMK, editor. Neonatology Pathophysiology and Management of the Newborn. Philadelphia: Lippincott Company; 2005. p. 1235–75.

Stoll B. Infections of the neonatal infant. In: Kliegman R, Behrman RE, Jenson HB, Stanton BF, editor. Nelson textbook of pediatrics. Philadelphia: WB Saunders Co; 2007. p. 794–801.

Shah G, Budhathoki S, Das BK, Mandal RN. Risk factors in early neonatal sepsis. Kathmandu University Medical Journal. 2006; 4: 187–91.

Ladfors L, Tessin I, Mattsson LA, Eriksson M, Seeberg S, Fall O. Risk factors for neonatal sepsis in offspring of women with prelabor rupture of the membranes at 34–42 weeks. J of perinatal med 1998; 26: 94–101.

Bhutta Z, Yusuf K. . Neonatal sepsis in Karachi: factors determining outcome and mortality J of Tropical Ped 1997; 43: 65–70.

Weinstein M, Towns ML, Quartery SM. The clinical significance of positive blood cultures in the 1990s: a prospective comprehensive evaluation of the microbiology, epidemiology and outcome of bacteremia and fungemia in adults. Clin Infect Dis 1997. 1997; 24: 584–602.

Aminullah A. Masalah terkini sepsis neonatorum. In: Hegar B, Trihono PP, Ifran EB, editor. Update in neonatal infections. Jakarta: Departemen Ilmu Kes Anak FKUI- RSCM; 2005. p. 1–15.

Bennel R, Nord CE. Development of the faecal anaerobic microflora after Caesarean section and treatment with antibiotics in newborn infants. Infection. 1987; 15: 332–6.

Sung N, Lee SG, Kim MJ, Kim YH, Yang S, Hwang IT, et al.

The changes of Intestinal normal flora in neonates for seven days postnatally. . Korean J Pediatr Gastroenterol Nutr. 2006; 9: 162–8.


  • There are currently no refbacks.

Copyright (c) 2017 Indonesian Journal of Tropical and Infectious Disease

View My Stats

IJTID Indexed by : 


IJTID (pISSN 2085-1103eISSN 2356-0991is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Lembaga Penyakit Tropis (Institute of Tropical Disease)

Universitas Airlangga

Kampus C Mulyorejo

Surabaya 60115