Early Management of Aspiration Pneumonia in an Infant With Suspected Laryngomalacia in A Resource-Limited Setting: A Case Report

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Laryngomalacia is the most common cause of congenital stridor in infants and can lead to feeding difficulties, failure to thrive, and respiratory distress. Diagnosis typically requires flexible fiberoptic laryngoscopy, which more often than not, not available in resource-limited settings. We report a 12-day-old male infant who presented to the emergency department with apnea following a choking episode. He required cardiopulmonary resuscitation and was admitted to the neonatal intensive care unit. Clinical findings included chest retractions, cyanosis, weight loss (from 3500g at birth to 2700g), and feeding difficulties. Chest radiograph showed right-sided perihilar infiltrates consistent with aspiration pneumonia. Despite initial clinical improvement, the infant developed new-onset positional stridor on day ten of hospitalization, particularly when supine. These findings raised strong suspicion of underlying laryngomalacia. These signs raised a strong clinical suspicion of laryngomalacia. Due to absence of flexible fiberoptic laryngoscopy, diagnosis could not be confirmed. The infant was stabilised with supportive care and feeding adjustments before being referred to a tertiary center for definitive evaluation and management. This case highlights the importance of prompt recognition and early stabilisation of neonates with aspiration-related complications and suspected airway anomalies, particularly in low-resource settings. Timely referral is essential to prevent deterioration and guide appropriate long-term management.
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Parkes WJ, Propst EJ. Advances in the diagnosis, management, and treatment of neonates with laryngeal disorders. Seminars in Fetal and Neonatal Medicine. 2016 Aug 1;21(4):270–6. DOI: 10.1016/j.siny.2016.03.003
Klinginsmith M, Winters R, Goldman J. Laryngomalacia. StatPearls [Internet]. 2024; https://www.ncbi.nlm.nih.gov/books/NBK544266/
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Landry AM, Thompson DM. Laryngomalacia: Disease Presentation, Spectrum, and Management. International Journal of Pediatrics. 2012;2012:1–6. DOI: 10.1155/2012/753526
Jaffal H, Isaac A, Johannsen W, Campbell S, El-Hakim HG. The prevalence of swallowing dysfunction in children with laryngomalacia: a systematic review. International Journal of Pediatric Otorhinolaryngology. 2020 Dec 1;139:110464. DOI: 10.1016/j.ijporl.2020.110464
Irace AL, Dombrowski ND, Kawai K, Watters K, Choi S, Perez J, et al. Evaluation of Aspiration in Infants with Laryngomalacia and Recurrent Respiratory and Feeding Difficulties. JAMA Otolaryngology - Head and Neck Surgery. 2019;145(2):146–51. DOI: 10.1001/jamaoto.2018.3642
Ha JF. Dysphagia in laryngomalacia: a prospective cohort study. Australian Journal of Otolaryngology. 2022;5. DOI: 10.21037/ajo-21-44
Thottam PJ, Simons JP, Choi S, Maguire R, Mehta DK. Clinical relevance of quality of life in laryngomalacia. Laryngoscope. 2016;126(5):1232–5. DOI: 10.1002/lary.25491
Bhatt J, Prager JD. Neonatal Stridor: Diagnosis and Management. Clinics in Perinatology. 2018;45(4):817–31. DOI: 10.1016/j.clp.2018.07.015
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Swallow Dysfunction. Ear, Nose and Throat Journal. 2019;98(10):613–6. DOI: 10.1177/0145561319847459
Leonard JA, Reilly BK. Laryngomalacia in the Premature Neonate. NeoReviews. 2021;22(10). DOI: 10.1542/neo.22-10-e653
Jain D, Jain S. Management of Stridor in Severe Laryngomalacia: A Review Article. Cureus. 2022;14(9). DOI: 10.7759/cureus.29585
Macedo RB, Dias MS, Salazar L, Alexandre P, Viveiros C, Pereira M, et al. Laryngomalacia and failure to thrive – A case report. Journal of Pediatric and Neonatal Individualized Medicine. 2024;13(2):e130202. https://jpnim.com/index.php/jpnim/article/view/e130202
Cohen O, Picard E, Joseph L, Schwartz Y, Sichel JY, Attal P. Supraglottoplasty for severe laryngomalacia. Can we predict success? International Journal of Pediatric Otorhinolaryngology. 2020;138(May):110333. DOI: 10.1016/j.ijporl.2020.110333
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