ANTI-INFLAMMATORY ACTIVITY OF STEM BARK DICHLOROMETHANE FRACTION Syzygium samarangense EXTRACT AS COX-2 INHIBITOR: A BIOINFORMATICS APPROACH
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Syzygium samarangense is a plant that is rich in flavonoid compounds. Previous research
revealed that the dichloromethane fraction from the stem bark extract contained four
bioactive compounds, namely, pinocembrin, uvangoletin, stercurensin, and aurentiacin,
which had good antioxidant activity. However, research on the potential of these four
compounds as an anti-inflammatory has not been revealed. This study aims to continue
previous research in revealing the potential of compounds in the dichloromethane fraction
of S. samarangense extract as an anti-inflammatory agent in silico COX-2 inhibitors. This
study uses in silico biocomputation, including drug-likeness analysis and molecular docking
analysis using COX-2 protein and the control drug rofecoxib. The results showed that there
are compounds that have the potential as anti-inflammatory compounds, namely
pinocembrin. However, further studies, such as in vitro and in vivo, are still needed to reveal
its potential as an anti-inflammatory agent
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