The Efficacy of Madeira Vine Leaf Extract Combined with Turmeric Rhizome Extract Gel Topically on Second-Degree Burn Wound in Albino Rats
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Burns is now considered one of the most destructive forms of trauma affecting humans and animals. This study aimed to determine the effect of Madeira vine leaf extract combined with 2% Turmeric rhizome extract (MVLTR) gel administered topically on second-degree burn wound in albino rats based on the number of fibroblasts. A total of 25 male rats weighed 200–300 grams were divided into five groups i.e. (C-) was normal skin, (C+) was burn and treated using 1% silver sulfadiazine, (T1) was burn and treated using 1.25% MVLTR gel, (T2) was burn and treated using 2.5% MVLTR gel, and (T3) was burn and treated using 5% MVLTR gel. The burn wound was performed on the right gluteus of rats, and the therapy was applied twice a day topically, starting after the burn wounds were made. Skin samples were collected on day 15. The histopathological examination was performed by counting fibroblast cells and then analyzed using One-way ANOVA, continued with the Duncan test. Based on the results showed that the C- group was significantly different compared to C+, T1, T2, and T3 groups. C+ had a significant difference with the T1 and T3 groups, meanwhile not significantly different from the T2 group. T2 was not significantly different from the C+ and T3 groups. In conclusion, MVLTR gel at 5% concentration has the potential to be an effective treatment for second-degree burns, as indicated by the increased number of fibroblasts.
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Copyright (c) 2023 Mirza Atikah Madarina Hisyam, Wiwik Misaco Yuniarti"¬, Sis Wisnuarti Theresia, Ira Sari Yudaniayanti, Bambang Sektiari Lukiswanto, Sri Agus Sudjarwo, Thomas Valentinus Widiyatno
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