Swandari Paramita, Muhammad Khairul Nuryanto

Abstract views = 3383 times | downloads = 1795 times


Background: Inflammation is a normal process in response to injury, but causes problems for the patient, including the appearance of pain, swelling, or fever. Anti-inflammatory agents generally used for those conditions, have several side effects to patients. Purpose: The objective of this research was to find alternative anti-inflammatory agents, especially from natural sources. Eleutherine bulbosa (Mill.) Urb. knew as “Bawang Dayak” belong to family Iridaceae is one of the natural sources for anti-inflammatory agents. This plant is known as traditional medicine in East Kalimantan and used as material in this research. Method: The experimental method of anti-inflammatory measurement using membrane stabilization activity for E. Bulbosa ethanol bulbs extracts. Result: The results showed that significant differences of EC50(p < 0.05) were achieved between indomethacin (26.39 ± 2.91) as the positive control with E. Bulbosa (52.87 ± 2.29). EC50 of E. bulbosa showed the potential anti-inflammatory activities with similar effectiveness to half indomethacin concentration. Conclusion: It could be concluded that E. bulbosa could be further developed as a new natural source of the anti-inflammatory agents.


Anti-inflammatory; Eleutherinebulbosa; membrane stabilization

Full Text:



Couto, C., Moraes, D., Cartagenes, M., Amaral, F., Guerra, R. 2016. Eleutherine bulbous (Mill.) Urb.: A review study. Journal of Medicinal Plants Research Vol. 10(21). Pp. 286–297.

Departemen Kesehatan RI. 2008. Farmakope Herbal Indonesia, 1st ed. Jakarta: Departemen Kesehatan RI.

Efendi, A., Ahmad, I., Ibrahim, A. 2015. Efek antimitosis ekstrak bawang dayak (Eleutherine americana L. Merr) terhadap sel telur bulu babi (Tripneustes gratilla Linn.). Jurnal Sains dan Kesehatan Vol. 1(3). Pp. 99–104.

Febrinda, A., Astawan, M., Wresdiyati, T., Yuliana, N. 2013. Kapasitas antioksidan dan inhibitor alfa glukosidase ekstrak umbi bawang dayak. Jurnal Teknologi dan Industri Pangan Vol. 24(2). Pp. 161–167.

Ifesan, B., Ibrahim, D., Voravuthikunchai, S. 2010. Antimicrobial activity of crude ethanolic extract from Eleutherine americana. Journal of Food Agriculture and Environment Vol. 8(3). Pp. 1233–1236.

Ifesan, B., Siripongvutikorn, S., Voravuthikunchai, S. 2009. Application of Eleutherine americana Crude Extract in Homemade Salad Dressing. Journal of Food Protection Vol. 72(3). Pp. 650–655.

Insanu, M., Kusmardiyani, S., Hartati, R. 2014. Recent Studies on Phytochemicals and Pharmacological Effects of Eleutherine americana Merr. Procedia Chemistry Vol. 13(2014). Pp. 221–228.

Kuntorini, E., Astuti, M., Nugroho, L. 2010. Struktur anatomi dan aktivitas antioksidan bulbus bawang dayak (Eleutherine americana Merr.) dari daerah Kalimantan Selatan. Berkala Penelitian Hayati Vol. 16. Pp. 1–7.

Kuntorini, E., Nugroho, L., 2010. Structural development and bioactive content of red bulb plant (Eleutherine americana): a traditional medicines for local Kalimantan people. Biodiversitas Vol. 11(2). Pp. 102–106.

Kusuma, I., Arung, E., Rosamah, E., Purwatiningsih, S., Kuspradini, H., Syafrizal, S., Astuti, J., Kim, Y., Shimizu, K. 2010. Antidermatophyte and antimelanogenesis compound from Eleutherine americana growth in Indonesia. Journal of Natural Medicines Vol. 64(2). Pp. 223–226.

Limsuwan, S., Voravuthikunchai, S. 2013. Anti-Streptococcus pyogenes Activity of Selected Medicinal Plant Extracts Used in Thai Traditional Medicine. Tropical Journal of Pharmaceutical Research Vol. 12(4), 535–540.

Omale, J., Okafor, P. 2008. Comparative antioxidant capacity, membrane stabilization, polyphenol composition and cytotoxicity of the leaf and stem of Cissus multistriata. African Journal of Biotechnology Vol. 7(17). Pp. 3129–3133.

Oyedapo, O., Akinpelu, B., Akinwunmi, K., Adeyinka, M., Sipeolu, F. 2010. Red blood cell membrane stabilizing potentials of extracts of Lantana camara and its fractions. International Journal of Plant Physiology and Biochemistry Vol. 2(4). Pp. 46–51.

Paramita, S., Yasir, Y., Yuniati, Y., Sina, I. 2018. Analisis Bioautografi Kromatografi Lapis Tipisdan Aktivitas AntibakteriEkstrak Etanol Bawang Tiwai (Eleutherine bulbosa (Mill.) Urb.) terhadap Methicillin-resistant Staphylococcus aureus (MRSA). Jurnal Sains dan Kesehatan Vol. 1(9). Pp. 470–478.

Pountos, I., Georgouli, T., Howard, B., Giannoudis, P. 2011. Nonsteroidal Anti- inflammatory Drugs: Prostaglandins, Indications, and Side Effects. International Journal of Interferon Cytokine and Mediator Research Vol. 3(1). 19–27.

Pratiwi, E., Wahdaningsih, S., Isnindar, I. 2013. Uji aktivitas antioksidan daun bawang merah (Eleutherine americana Merr.) dengan metode DPPH (2,2-difenil-1-pikrilhidrazil). Traditional Medicine Journal Vol. 18. Pp. 9–16.

Rathee, P., Chaudhary, H., Rathee, S., Rathee, D., Kumar, V., Kohli, K. 2009. Mechanism of Action of Flavonoids as Anti-inflammatory Agents: A Review. Inflammation and Allergy Drug Targets Vol 8(3). Pp. 229–235.

Siew, C., Francis, K. 2010. NSAID-induced Gastrointestinal and Cardiovascular Injury. Current Opinion In Gastroenterology Vol. 26(6). 611–617.

Souza, T., Marques, G., Vieira, A., Freitas, J. 2012. State of the Art of Anti-inflammatory Drugs. In: Badria, F. (Ed.), Pharmacotherapy. Intech, Rijeks, Croatia. Pp. 116–140.

The Plant List, 2018. Eleutherine bulbosa (Mill.) Urb. Available from: Accessed: 5 January 2018.


  • There are currently no refbacks.

Copyright (c) 2019 Journal Of Vocational Health Studies

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

This Journal is Indexed by: 


Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.