PHYTOCHEMICAL, USE IN ETHNOMEDICINE, AND THERAPEUTIC ACTIVITIES OF MARCHANTIA GENUS

Dicki Bakhtiar Purkon; Faizah Min Fadhlillah; Tonny Cortis Maigoda; Maria Immaculata Iwo; Adreanus Andaja Soemardji; Ainun Nadhifah; Yayat Sudaryat

doi:10.20473/jvhs.V5.I3.2022.174-185

Authors

Dicki Bakhtiar Purkon Department of Pharmacology and Clinical Pharmacy, Poltekkes Kemenkes Bandung, Indonesia https://orcid.org/0000-0001-8188-1580
Faizah Min Fadhlillah
faizah@uniga.ac.id
Department of Pharmaceutical Biology, Faculty of Mathematics and Science, Universitas Garut, Indonesia https://orcid.org/0000-0002-2579-5781
Tonny Cortis Maigoda Department of Pharmaceutical Biology, Faculty of Mathematics and Science, Poltekkes Kemenkes Bengkulu, Indonesia https://orcid.org/0000-0001-5243-0078
Maria Immaculata Iwo Department of Pharmacology – Clinical Pharmacy, School of Pharmacy, Institut Teknologi Bandung, Indonesia https://orcid.org/0000-0003-2856-939X
Adreanus Andaja Soemardji Institut Teknologi Bandung, Indonesia
Ainun Nadhifah Pusat Penelitian Konservasi Tumbuhan dan Kebun Raya – Kebun Raya Cibodas, LIPI, Indonesia https://orcid.org/0000-0003-0575-4306
Yayat Sudaryat Department of Pharmaceutical and Analytical Chemistry, Study Program of D-3 Pharmacy, Department of Pharmacy, Poltekkes Kemenkes Bandung, Indonesia

Vol. 5 No. 3 (2022): March 2022 | JOURNAL OF VOCATIONAL HEALTH STUDIES

Literature Review

March 28, 2022

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Background: Liverworts are a group of plants from the Marchantia genus containing various biologically active compounds and comprised of 65 species worldwide. This plant species belongs to the Marchantiaceae family, which was used empirically in China, North America, Ancient Greece, and Indonesia to treat open wounds, burns, hepatotoxicity, and infection prevention. Now, liverworts have great potential as medicinal and nutraceutical products because of their phytochemical content and diversity of pharmacological activities. Purpose: This review focuses on secondary metabolites obtained from the thalloid and whole plant parts (herbs) and the compilation of their pharmacological activities, which are still poorly documented. Review: This review article obtained related information through extensive international journals (online) scientific databases and offline (books) related to all searches of the species of the genus Marchantia which included: phytochemical content (secondary metabolites) and various pharmacological activities which were collected and compared all results of literature studies from various aspects. Some of the secondary metabolites are Marchantin A, B, D dan E; Paleatin B; Perrottetin F, and Plagiochin E, which have various pharmacological activities. Various results regarding all the therapeutic properties of the genus Marchantia have been produced in the world such as: antibacterial, antifungal, antioxidant, cytotoxic activity, anti-inflammatory, cardiotonic, hepatoprotective, muscle relaxant, antiosteoporosis, and skin care. Conclusion: Therefore, the potential for the development of medicinal, supplementary and nutraceutical products from various Marchantia species is very large and broad for the future.

Purkon, D. B., Fadhlillah, F. M., Maigoda, T. C., Iwo, M. I., Soemardji, A. A., Nadhifah, A., & Sudaryat, Y. (2022). PHYTOCHEMICAL, USE IN ETHNOMEDICINE, AND THERAPEUTIC ACTIVITIES OF MARCHANTIA GENUS. Journal of Vocational Health Studies, 5(3), 174–185. https://doi.org/10.20473/jvhs.V5.I3.2022.174-185

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Adom, D., 2018. Traditional Cosmology and Nature at The Bomfobiri Wildlife Sanctuary of Ghana. Nat. Conserbation Res. Vol.3(1), Pp. 35-37.

Ahmed, M., Sikandar, A., Iqbal, M.F., Javeed, A., 2019. Phytochemical Screening, Total Phenolic and Flavonoids Contents and Antioxidant Activities of Citrullus colocynthis L. and Cannabis Sativa L. Appl. Ecol. Environ. Res. Vol.17(3), Pp. 6961-6979.

Alam, A., Sharma, V., Sharma, S.C., Kumari, P., 2012. Antibacterial Activity of The Alcoholic Extracts of Entodon nepalensis Mizush. Against some Pathogenic Bacteria. Rep. Opin. Vol.4(10), Pp. 44-47.

Altemimi, A., Lakhssassi, N., Baharloue, A., Watson, D.G., Lightfoot, D.A., 2017. Phytochemicals: Extraction, Isolation, and Identification of Bioactive Compounds from Plant Extracts. Plants. Vol.6(4), Pp. 1-23.

Asakawa, Y., 2007. Biological Active Compounds from Bryophytes. Pure Appl. Chem. Vol.79(4), Pp. 557-580.

Asakawa, Y., 2008. Liverworts-Potential Source of Medicinal Compounds. Curr. Pharm. Des. 3067–3088.

Asakawa, Y., 2012. Liveworths-Potential Source of Medicinal Compounds. Med. Aromat. Plants. Vol.1(3), Pp. 3067-3088.

Bowman, J.L., 2016. A Brief History of Marchantia from Greece to Genomics. Plant Cell Physiol. Vol.57(2), Pp.210-229.

Cao, H., Xiao, J.B., Xu, M., 2007. Comparison of Volatile Components of Marchantia convulta Obtained by Supercritical Carbon Dioxide and Petrol Ether Extraction. J. Food Compos. Anal. Vol.20(1), Pp. 45-51.

Colegate, S.M., Molyneux, R.J., 2008. Bioactive Natural Products-Detection, Isolation, and Structural Determination, 2nd ed. CRC Press.

Coritico, F., Amoroso, V.B., 2020. Threatened Lycophytes and Ferns in Four Protected Areas of Mindanao, Philippines. Nat. Conserv. Res. Vol.5(4), Pp. 78-88.

Fadhilla, R., Iskandar, E.A., Kusumaningrum, H.D., 2012. Tumbuhan Lumut Hati (Marchantia paleacea) terhadap Bakteri Patogen dan Perusak Pangan. J. Teknol. dan Ind. Pangan Vol.23(2), Pp. 126-131.

Fernando, C.D., Soysa, P., 2014. Total Phenolic, Flavonoid Contents, In-vitro Antioxidant Activities and Hepatoprotective Effect of Aqueous Leaf Extract of Atalanta ceylanica. BMC Complement. Altern. Med. Vol.395.

Gahtori, D., Chatuverdi, P., 2011. Antifungal and Antibacterial Potential of Methanol and Chloroform Extracts of Marchantia polymorpha L. Arch. Pathol. Plant Prot. Vol.44(8), Pp. 726-731.

García-Ruiz, A., Cuevaa, C., M., E., González-Rompinelli, Yuste, M., Torres, M., J.Martín-Álvarez, P., Bartolomé, B., Moreno-Arribas, M.V., 2012. Antimicrobial henolic Extracts able to Inhibit Lactic Acid bacteria Growth and Wine Malolactic Fermentation. Food Control. Vol.28(2), Pp. 212-219.

Gokbulut, A., Satilmis, B., Batcioglu, K., Cetin, B., Sarer, E., 2012. Antioxidant and Lutein Content of Marchantia Polymorpha L. TUBITAK (Turk J Biol). Vol.36, Pp. 381-385.

Heinrichs, J., Gradstein, S.R., Wilson, R., Schneider, H., 2005. Towards a Natural Classification of Liverworts (Marchantiophyta) based on The Chloroplast Gene RBCL and Tatipamula. Cryptogam. Bryol. Vol.25(2), Pp. 131-150.

Hossain, M.A., Al-Raqmi, K.A.S., Al-Mijizy, Z.H., Weli, A.M., Al-Riyami, Q., 2013. Study of Total Phenol, Flavonoids Contents and Phytochemical Screening of Various Leaves Crude Extract of Locally Grown. Asian Pac. J. Trop. Biomed. Vol.3(9), Pp. 705-710.

Jensen, S., Omasdottir, S., Thorsteinsdottir, J.B., Ogmundsdottir, H.M., Olafsdotttir, E.S., 2012. Synergistic Cytotoxic Effect of The Microtubule Inhibitor Marchantia A from Marchantia polymorpha and The Aurora Kinase Inhibitor MLN8237 on Breast Cancer Cells in Vitro. Planta Med. Vol.78(5), Pp. 448-454.

Jian-Bo, R., F.-L., M., X., 2005. Anti-Hepatitis B Virus Activity of Flavonoids from Marchantia convoluta. Iran. J. Pharmacol. Ther. Vol.4(2), Pp. 128-131.

Kamory, E., Keseru, G.M., Papp, B., 1995. Isolation and Antibacterial Activity of Marchantin A, A Cyclic Bis(bibenzyl) Constituent of Hungarian Marchantia polymorpha. Planta Med. Vol.61(4), Pp. 387-388.

Karmakar, S., Paul, S., Biswas, N.M., Khanam, J., Kar, S.K., Mukherjee, H., Poddar, S., 2020. A Pharmacological Audit and Advancement on The Recent Trend of Research on Ficus benghalensis L. including Its In-vitro Hepatoprotective Activity. Clin. Phytoscience. Vol.6(1), Pp. 1-13.

Katsunuma, N., 1997. Molecular Mechanisms of Bone Collagen Degradation in Bone Resorption. J. Bone Miner. Metab. Vol.15, Pp. 1-8.

Krishnamurthy, R., Animasaun, D.A., T., P.R., Ingalhalli, R., 2016. Phytochemical Constituents and Hypoglycemic Effect of Gymnema Extracts from Big and Small Leaf Varieties. Indones. J. Pharm. Vol.27(2), Pp. 59-65.

Lahlou, E., Hashimoto, T., Asakawa, Y., 2000. Chemical Constituents of The Liverworts Plagiochasma japonica and Marchantia toscana. Hattori Shokubutsu Kenkyujo Hokoku. Vol.275(88), Pp. 271-275.

Lailaty, I.Q., Muhaimin, M., Handayni, A., Efendi, M., Nadhifah, A., Noviady, I., 2016. Potensi Tumbuhan Koleksi Kebun Raya Cibodas sebagai Obat Antimalaria Masa Depan. J. Tumbuh. Obat Indones. J. Indones. Medicial Plant. Vol.9(1), Pp. 37-57.

Long, D.G., Forrest, L.L., Villarreal, J.C., Crandall-Stotler, B.J., 2016. Taxonomic Changes in Marchantiaceae, Corsiniaceae and Cleveaceae (Marchantiidae, Marchantiophyta). Phytotaxa. Vol.252(1), Pp. 077-080.

M., G.G., S., M.G., Lawarence, B., Kumara, M., 2016. Bryophytes, The Ignores Medicinal Herbals of The Biological World - A Search at Neyyar Wildlife Sanctuary, Trivandrum, Kerala. Kongunadu Res. J. Vol.(3)1, Pp. 22-25.

Maigoda, T., Judiono, J., Purkon, D.B., Haerussana, A.N.E.M., Mulyo, G.P.E., 2022. Evalution of Peronema canescens Leaves Extract:Fourier Transform Infrared Analysis. Open Access Maced. J. Med. Sci. Vol.10(A), Pp. 117-124.

Matsunaga, Y., Saibara, T., Kido, H., Katunuma, N., 1993. Participation of Cathepsin B in Processing of Antigen Presentation MHC Class II. FEBS Lett. Vol.324(3), Pp.325-330.

Mewari, N., Kumar, P., 2011. Evaluation of Antifungal Potential of Marchantia polymorpha L. Arch. Phytopathol. Plant Prot. Vol.44(8), Pp. 804-812.

Mishara, R., Pandey, V.K., Chandra, R., 2014. Potential of Bryophytes as Therapeutics. Interantional J. Pharm. Sci. Res. Vol.5(9), Pp. 3584-3593.

Nurhaeni, N., Hardi, J., Gladys, G., 2019. Uji Aktivitas Antioksidan Ekstrak Lumut Hati (Marchantia polymorpha). KOVALEN J. Ris. Kima Vol.5(3), Pp. 315-321.

Pamungkas, B.T., Muktiwardojo, M., Rostinawati, T., 2019. Review:Antibacterial Activities of Various Parts of Mengkudu (Morinda citrifolia L.) Plants on Some Species of Bacteria. J. Trop. Pharm. Chem. Vol.4(5), Pp. 244-249.

Parihar, G., Balekar, N., 2016. Calotropis Procera:A . Phytochemical and Pharmacological Review's Liverwoth Ethanol Extract in BALB/c Mice. Thai J. Pharm. Sci. Vol.40(3), Pp. 115-131.

Purkon, D.B., Iwo, M.I., Soemardhi, A.A., Rahmawati, S.F., Fadhillah, F.M., Nadhifah, A., 2021a. Immunostimulant Activity of Marchantia paleacea Bertol. Herb Liverworth Ethanol Extract in BABLB/c Mice. Indones. J. Pharm. Vol.32(4), Pp. 464-473.

Purkon, D.B., Kusmiyati, M., Trinovani, E., Fadhillah, F.M., 2021b. Peningkatan Pemahaman dan Keterampilan Mitra Posyandu dalam Pembuatan Minuman Tradisional Herbal sebagai Imunostimulan. J. SOLMA Vol.10(2), Pp. 210-219.

Raihan, C., Nurasiah, N., Zahara, N., 2018. Keanekaragaman Tumbuhan Lumut (Bryophyta) di Air terjun Peucari Bueng Jantho Kabipaten Aceh Besar. Prosding Semin. Nas. Biot. Vol.6(1), Pp. 439-451.

Riaji, L., 2019. Review of Phytochemicals and Its Biological Activities and Contemporary Nutraceuticals. Jouranl Triopical Pharm. Chem. Vol.4(6), Pp. 298-310.

Sabovljevic, A., Sokovic, M., Glamoclija, J., Ciric, A., Vujicic, M., Pejin, B., Sabovijevic, M., 2011. Bio-activities of Extracts from Some Azenicallt Farmed and Naturally Grown Bryophytes. Jouranl Med. Plants Res. Vol.5(4), Pp. 565-571.

Solihat, S.S., Kurnia, M.F., 2021. Identifikasi Morfologi Marchantia polymorpha and Leucobryum glaucum di Bojong Menteng, Kecamatan Cijeruk, Identification of Morphology of Marchantia polymorpha and Leucobryum glaucum in. Trop. Biosci. J. Bilogical Sci. Vol.1(1), Pp. 29-38.

Suire, C., Bouvier, F., Backhaus, R.A., Begu, D., Bonneu, M., Camara, B., 2000. Cellular Localization of Isoprenoid Biosynthetic Enzymes in Marchantia polymorpha. Plant Physiol. Vol.124(3), Pp. 971-978.

Sun, L.M., Lv, B.B., Cheng, A.X., Wu, X.Z., Lou, H.X., 2009. The Effect of Plagiochin E alone and in Combination with Fluconazole on The Ergosterol Biosynthesis of Candida albicans. Biol. Pharm. Bull. Vol.32(1), Pp. 36-40.

Suprapti, B., Suharjono, S., Raising, R., Yulistiani, Y., Izzah, Z., Nilamsari, W.P., Wulaningrum, P.A., Bactiar, A., 2018. Effects of Probiotics and Vitamin B Supplementation on IFN-Î³ and IL-12 Levels during Intensive Phase Treatment of Tuberculosis. Indones. J. Pharm. Vol.29(2), Pp. 80-85.

Tag, H., Das, A.K., Loyi, H., 2007. Anti-inflammatory Plants used by The Khamti Tribe of Lohit District in Eastern Arunachal Pradesh, India. Nat. Prod. Radiance Vol.6(4), Pp. 334-340.

Viet, H. ho, Lagu, S.B., Tatipamula, V.B., 2022. Moss Bryum Weigelii Spreng Improves Survival in Septic Rats Induced by Cecal Ligation and Puncture. Thai J. Pharm. Sci. Vol.45(5), Pp. 387-393.

Vishiya N, M., 2018. Aktivitas Antimikroba dari Ekstrak Ascidian Herdmania momus pada Mikroba Patogen Manusia. Pharmacon Vol.7(3), Pp. 338-347.

Von-Konrat, M., Renner, M.A.M., Soderstron, L., Hagborg, A., 2008. Chapter Nine:Early Land Plants Today: Liverwort Species Diversity and The Relationship with Higher Taxonomy and Higher Plants. Fieldiana Bot. Vol.47(1), Pp. 91-104.

WHO, 1998. Quality Control Methods for Medicinal Plant Materials. Universal Copyright Convention, England.

Wu, X.-Z., Cheng, A.-X., Sun, L.-M., Sun, S.-J., Lou, H.-X., 2009. Plagiochin, An Antifungal bis (bibenzyl), Exerts Its Antifungal Activity through Mitochondrial Dysfunction-induced Reactive Oxygen Species Accumulation in Candida albicans. Biochim. Biophys. Acta Vol.17908, Pp. 770-777.

Wu, X., Cheng, A., Sun, L., Lou, H., 2008. Effect of Plagiochin E, An Antifungal Marcocyclic bis(bibenzyl), on Cell Wall Chitin Synthesis in Candida Albicans. Acta Pharmacolohica Sin. Vol.29(12), Pp. 1478-1485.

Xiao, J., Jiang, X., Chen, X., 2005. Antibacterial, Anti-inflammatory, and Diuretic Effect of Sinapic Acid and Their Structure-antioxidant Activity Relationship. African J. Tradit. Complement. Altern. Med. Vol.2(3), Pp. 244-252.

Yang, J., Chen, J., Hao, Y., Liu, Y., 2021. Identification of The DPPH Radical Scavenging Reaction Adducts of Ferulic Acid and Sinapic Acid and their Structure-antioxidant Activity Relationship. LWT Vol.146, Pp. 111411.

Yayintas, O.T., Irkin, L.C., 2018. Bryophytes as Hidden Treasure. J. Sci. Perspect. Vol.2(1), Pp. 71-83.