SERUM ELECTROLYTE LEVELS IN HEART FAILURE PATIENTS WITH A HYPERTENSION HISTORY

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Background: Knowing the description of serum electrolytes in those with a history of hypertension and congestive heart failure is critical. Purpose: The purpose of this study is to look into the estimation of serum electrolytes, the correlation between serum electrolytes (sodium (Na+), potassium (K+), chlorine (Cl-)) levels with blood pressure, and the demographic characteristics of heart failure patients with a history of hypertension. Method: A retrospective design was used in this study, which used progress records (e.g., participant demographic data, medical history, and clinical laboratory tests such as serum electrolytes and blood chemistry) from patients with hypertension and Heart Failure (HF) who were hospitalized. Result: The present study established no correlation between serum electrolyte levels and blood pressure. The highest of Na+ levels were 169 mEq/L, K+ 6.4 mEq/L, and Cl- 119 mEq/L. Most participants had the habit of not smoking (87 people, 79.8%) and not consuming alcohol (91 people, 83.5%). Demographic characteristics such as gender, smoking habits, and alcohol consumption had no significant impact on serum electrolyte levels, except for a history of alcohol consumption on sodium levels, which had a significant effect (p-value = 0.014). Furthermore, an absence of correlation was observed between demographic factors and blood pressure. Conclusion: A lack of relationship between serum electrolyte levels and blood pressure. Similarly, demographic characteristics were not correlated with blood pressure. HF patients with a history of hypertension show normal serum electrolyte levels, but a significant relationship between alcohol consumption habits and sodium levels was found.
Adrogué, H.J., 2017. Hyponatremia in Heart Failure. Methodist DeBakey Cardiovascular Journal Vol. 13(1), Pp. 40.
Casey, B., Hofstrand, R., Patel, D., Bahekar, A., Chapa-Rodriguez, A., 2023. Hypokalemia-Induced Cardiac Arrest. Cureus Vol. 15(2), Pp. e35034.
Cavusoglu, Y., Kaya, H., Eraslan, S., Yilmaz, M.B., 2019. Hyponatremia is Associated with Occurrence of Atrial Fibrillation in Outpatients with Heart Failure and Reduced Ejection Fraction. Hellenic Journal of Cardiology Vol. 60(2), Pp. 117-121.
Chandini, Chandini, Mathai, P.J., 2017. Serum Electrolytes Levels in Patients with Alcohol Dependence Syndrome. International Journal of Contemporary Medical Research Vol. 4(5), Pp, 992-997.
Cuthbert, J.J., Pellicori, P., Rigby, A., Pan, D., Kazmi, S., Shah, P., Clark, A.L., 2018. Low Serum Chloride in Patients with Chronic Heart Failure: Clinical Associations and Prognostic Significance. European Journal of Heart Failure Vol. 20(10), Pp. 1426-1435.
Eid, H.A., Moazen, E.M., Elhussini, M., Shoman, H., Hassan, A., Elsheikh, A., Rezk, A., Moursi, A., Atef, M., Kabil, A., 2022. The Influence of Smoking on Renal Functions Among Apparently Healthy Smokers. Journal of Multidisciplinary Healthcare Vol. 15, Pp. 2969-2978.
Ferreira, J.P., Butler, J., Rossignol, P., Pitt, B., Anker, S.D., Kosiborod, M., Lund, L.H., Bakris, G.L., Weir, M.R., Zannad, F., 2020. Abnormalities of Potassium in Heart Failure. Journal of The American College of Cardiology Vol.75(22), Pp. 2836-2850.
Flack, J.M., Adekola, B., 2020. Blood Pressure and The New ACC/AHA Hypertension Guidelines. Trends in Cardiovascular Medicine Vol. 30(3), Pp. 160-164.
Fonseca, C., 2017. Comentário A “Epidemiology of Heart Failure: The Prevalence of Heart Failure and Ventricular Dysfunction in Older Adults Over Time. A Systematic Review". Revista Portuguesa de Cardiologia Vol. 36(5), Pp. 405-407.
Gerber, Y., Weston, S.A., Redfield, M.M., Chamberlain, A.M., Manemann, S.M., Jiang, R., Killian, J.M., Roger,V.L., 2015. A Contemporary Appraisal of The HeartFailure Epidemic in Olmest County, Minnesota.JAMA Internal Medicine. Vol. 175(6), Pp. 996-1004.
Grodin, J.L., Simon, J., Hachamovitch, R., Wu, Y., Jackson, G., Halkar, M., Starling, R.C., Testani, J.M., Tang, W.H.W., 2015. Prognostic Role of Serum Chloride Levels in Acute Decompensated Heart Failure. Journal of The American College of Cardiology Vol. 66(6), Pp. 659-666.
Heidenreich, P.A., Bozkurt, B., Aguilar, D., Allen, L.A., Byun, J.J., Colvin, M.M., Deswal, A., Drazner, M.H., Dunlay, S.M., Evers, L.R., Fang, J.C., Fedson, S.E., Fonarow, G.C., Hayek, S.S., Hernandez, A.F., Khazanie, P., Kittleson, M.M., Lee, C.S., Link, M.S., Milano, C.A., Nnacheta, L.C., Sandhu, A.T., Stevenson, L.W., Vardeny, O., Vest, A.R., Yancy, C.W., 2022. 2022 AHA/ACC/HFSA Guideline for The Management of Heart Failure: A Report of The American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation Vol. 145(18), Pp. e895-e1032.
Hermida, R.C., Ayala, D.E., Fernández, J.R., Mojón, A., Smolensky, M.H., 2018. Hypertension: New Perspective on Its Definition and Clinical Management by Bedtime Therapy Substantially Reduces Cardiovascular Disease Risk. European Journal of Clinical Investigation Vol. 48(5), Pp. e12909.
Hou, X., Xu, W., Zhang, C., Song, Z., Zhu, M., Guo, Q., Wang, J., 2023. L-Shaped Association of Serum Chloride Level with All-Cause and Cause-Specific Mortality in American Adults: Population-Based Prospective Cohort Study. JMIR Public Health Surveill. Vol. 9, Pp. e49291.
Kammerlander, A.A., 2019. With a Grain of Salt: Sodium Levels in Heart Failure. International Journal of Cardiology Vol. 290, Pp. 125-126.
Kataoka, H., 2017. Proposal for Heart Failure Progression Based on The ‘Chloride Theory’: Worsening Heart Failure with Increased vs. Non-Increased Serum Chloride Concentration. ESC Heart Fail Vol. 4(4), Pp. 623-631.
Mahmood, S.S., Wang, T.J., 2013. The Epidemiology of Congestive Heart Failure: The Framingham Heart Study Perspective. Global Heart Vol. 8(1), Pp. 77-82.
Malik, A., Brito, D., Vaqar, S., Chhabra, L., 2024. Congestive Heart Failure. StatPearls Publishing, Treasure Island (FL).
Meenashi Sundaram, D., Madesh, V.P., Rambrahma Reddy, D., Baliga, K., 2023. Multiple Dyselectrolytemia in A Chronic Alcohol Abuser: A Case Report. Cureus Vol. 15(3), Pp. e36389.
Messerli, F.H., Rimoldi, S.F., Bangalore, S., 2017. The Transition from Hypertension to Heart Failure: Contemporary Update. JACC Heart Fail Vol. 5(8), Pp. 543-551.
Omar, H.R., Charnigo, R., Guglin, M., 2017. Prognostic Significance of Discharge Hyponatremia in Heart Failure Patients with Normal Admission Sodium (from The ESCAPE Trial). The American Journal of Cardiology Vol. 120(4), Pp. 607-615.
Palmer, B.F., Clegg, D.J., 2017. Electrolyte Disturbances in Patients with Chronic Alcohol-Use Disorder. The New England Journal of Medicine Vol. 377(14), Pp. 1368-1377.
Peng, S., Peng, J., Yang, L., Ke, W., 2022. Relationship between Serum Sodium Levels and All-Cause Mortality in Congestive Heart Failure Patients: A Retrospective Cohort Study based on The Mimic-III Database. Frontiers in Cardiovascular Medicine Vol. 9, Pp. 1082845.
Pluteanu, F., Nikonova, Y., Holzapfel, A., Herzog, B., Scherer, A., Preisenberger, J., Plačkić, J., Scheer, K., Ivanova, T., Bukowska, A., Goette, A., Kockskämper, J., 2018. Progressive Impairment of Atrial Myocyte Function during Left Ventricular Hypertrophy and Heart Failure. Journal of Molecular and Cellular Cardiology Vol. 114, Pp. 253-263.
Rebat, B.W., Al-Sabbagh, J.K., Habeeb, Z.T., Al-Khafaji, N.M., Jawad, R.A., 2020. Effect of Cigarette Smoking on Some Electrolytes Levels in Men Live in City of Karbala. AIP Conference Proceedings Vol. 2290(1), Pp. 020031.
Relias and Nurse. 2024. “Understanding Normal Electrolyte Levels: A Guide for Nurses.” Nurse.Com. 2024. https://www.nurse.com/nursing-resources/how-to-guides/normal-electrolyte-levels-nurses-guide/
Ríos-González, B.E., Saldaña-Cruz, A.M., Gallardo-Moya, S.G., Brambila-Tapia, A.J.L., 2024. Sex Differences in The Relationship between Personal, Psychological and Biochemical Factors with Blood Pressure in A Healthy Adult Mexican Population: A Cross-Sectional Study. Journal of Clinical Medicine Vol. 13(2), Pp. 378.
Rossignol, P., Coats, A.J., Chioncel, O., Spoletini, I., Rosano, G., 2019. Renal Function, Electrolytes, and Congestion Monitoring in Heart Failure. European Heart Journal Supplements Vol. 21(Supplement_M), Pp. M25-M31.
Shrimanker, I., Bhattarai, S., 2024. Electrolytes. In: StatPearls. StatPearls Publishing, Treasure Island (FL).
Şorodoc, V., Asaftei, A., Puha, G., Ceasovschih, A., Lionte, C., Sîrbu, O., Bologa, C., Haliga, R.E., Constantin, M., Coman, A.E., Petriș, O.R., Stoica, A., Şorodoc, L., 2023. Management of Hyponatremia in Heart Failure: Practical Considerations. Journal of Personalized Medicine Vol. 13(1), Pp. 140.
Sterns, R.H., Gottlieb, S.S., 2024. Hyponatremia in Patients with Heart Failure - UpToDate. UpToDate.
Tackling, G., Borhade, M.B., 2024. Hypertensive Heart Disease. StatPearls Publishing, Treasure Island (FL).
Tanai, E., Frantz, S., 2015. Pathophysiology of Heart Failure. Comprehensive Physiology Vol. 6(1), Pp. 187-214.
Taylor, C.J., Ordóñez-Mena, J.M., Jones, N.R., Roalfe, A.K., Lay-Flurrie, S., Marshall, T., Hobbs, F.D.R., 2021. National Trends in Heart Failure Mortality in Men and Women, United Kingdom, 2000–2017. European Journal of Heart Failure Vol. 23(1), Pp. 3-12.
Ter Maaten, J.M., Damman, K., Hanberg, J.S., Givertz, M.M., Metra, M., O’Connor, C.M., Teerlink, J.R., Ponikowski, P., Cotter, G., Davison, B., Cleland, J.G., Bloomfield, D.M., Hillege, H.L., van Veldhuisen, D.J., Voors, A.A., Testani, J.M., 2016. Hypochloremia, Diuretic Resistance, and Outcome in Patients with Acute Heart Failure. Circulation. Heart Failure Vol. 9(8), Pp. e003109.
Usman, S., Irwan, A.M., Arafat, R., 2022. Family Involvement in Low-Salt Diet for Hypertensive Older Adults. Working with Older People Vol. 7(1), Pp. 1-14.
Van Nuys, K.E., Xie, Z., Tysinger, B., Hlatky, M.A., Goldman, D.P., 2018. Innovation in Heart Failure Treatment: Life Expectancy, Disability, and Health Disparities. JACC Heart Fail Vol.6(5), Pp. 401-409.
Verbrugge, F.H., Steels, P., Grieten, L., Nijst, P., Tang, W.H.W., Mullens, W., 2015. Hyponatremia in Acute Decompensated Heart Failure. Journal of The American College of Cardiology Vol. 65(5), Pp. 480-492.
Whelton, P.K., Carey, R.M., Aronow, W.S., Casey, D.E., Collins, K.J., Dennison Himmelfarb, C., DePalma, S.M., Gidding, S., Jamerson, K.A., Jones, D.W., MacLaughlin, E.J., Muntner, P., Ovbiagele, B., Smith, S.C., Spencer, C.C., Stafford, R.S., Taler, S.J., Thomas, R.J., Williams, K.A., Williamson, J.D., Wright, J.T., 2018. Guideline for The Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of The American College of Cardiology. Hypertension Vol. 71(6),Pp. e13-e115.
Zandijk, A.J.L., van Norel, M.R., Julius, F.E.C., Sepehrvand, N., Pannu, N., McAlister, F.A., Voors, A.A., Ezekowitz, J.A., 2021. Chloride in Heart Failure: The Neglected Electrolyte. JACC Heart Fail Vol. 9(12), Pp. 904-915.
Zhang, Y., Peng, R., Li, X., Yu, J., Chen, X., Zhou, Z., 2018. Serum Chloride as A Novel Marker for Adding Prognostic Information of Mortality in Chronic Heart Failure. Clinica Chimica Acta; International Journal of Clinical Chemistry Vol. 483, Pp. 112-118.
Ziaeian, B., Fonarow, G.C., 2016. Epidemiology and Aetiology of Heart Failure. Nature Reviews. Cardiology. Vol. 13(6), Pp. 368-378.
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