THE DUAL BENEFITS OF HIGH-INTENSITY INTERVAL TRAINING: IMPROVING COGNITION AND REDUCING BODY WEIGHT IN SCHIZOPHRENIA PATIENTS ON RISPERIDONE
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This quasi-experimental study investigated the effects of High-Intensity Interval Training (HIIT) on weight loss and cognitive function in patients with schizophrenia treated with risperidone. Conducted at Dadi Regional Special Hospital, South Sulawesi, Indonesia, the study included 40 participants who met the inclusion criteria, including males aged 20–40 years, with disease onset of fewer than five years, and receiving risperidone therapy (4–6 mg/day). The exclusion criteria included severe organic comorbidities and recent substance use. The participants were divided into treatment and control groups, with the former undergoing 30 HIIT sessions over 10 weeks. Each session lasted 25 min, incorporating warm-up, core HIIT, and cool-down phases, with heart rates monitored to ensure anaerobic intensity (80–90% of maximum heart rate). The results showed a significant weight reduction in the treatment group (mean decrease: 0.475 kg, p < 0.001), indicating the potential of HIIT to mitigate risperidone-induced weight gain. Cognitive performance, assessed via the Schizophrenia Cognitive Rating Scale (SCoRS v BI), improved in both groups, with no significant differences between them (p > 0.05). However, greater improvement was observed in the treatment group. This study supports the integration of HIIT as adjunct therapy for schizophrenia, offering the dual benefits of cognitive enhancement and weight management. Further research incorporating genetic factors and advanced monitoring tools is needed to refine these findings.
Alan, B. and Kültür, S. (2013). Change in metabolic parameters and weight in response to risperidone monotherapy in young children with nonpsychotic disorders: a prospective open‐label study. Child and Adolescent Mental Health, 20(1), 20-25. https://doi.org/10.1111/camh.12033
Ali, I. (2014). Impact of combination interferon therapy on the body weight, body fat and lean body mass of chronic hcv infected patients. Journal of Antivirals & Antiretrovirals, 06(01). https://doi.org/10.4172/jaa.1000087
Andrews, S. C., Curtin, D., Hawi, Z., Wongtrakun, J., Stout, J. C., & Coxon, J. P. (2020). Intensity Matters: High-Intensity Interval Exercise Enhances Motor Cortex Plasticity More Than Moderate Exercise, 30(1), 101-112. Cerebral Cortex.
Bardazzi, F., Balestri, R., Baldi, E., Antonucci, A., Tommaso, S., & Patrizi, A. (2010). Correlation between bmi and pasi in patients affected by moderate to severe psoriasis undergoing biological therapy. Dermatologic Therapy, 23, S14-S19. https://doi.org/10.1111/j.1529-8019.2009.01281.x
Chen, K., Zhang, X., Feng, W., Li, Y., Xiu, M., & Chen, D. (2019). Effects of risperidone on glucose lipid metabolism and bodyweight in drug-naïve first episode chinese han patients with schizophrenia: a prospective study. https://doi.org/10.21203/rs.2.12083/v1
Cooper, S., Reynolds, G., Barnes, T., England, E., Haddad, P., Heald, A., … & Smith, J. (2016). Bap guidelines on the management of weight gain, metabolic disturbances and cardiovascular risk associated with psychosis and antipsychotic drug treatment. Journal of Psychopharmacology, 30(8), 717-748. https://doi.org/10.1177/0269881116645254
Dowthwaite, J., Rosenbaum, P., Sames, C., & Scerpella, T. (2014). Muscle function, dynamic loading, and femoral neck structure in pediatric females. Medicine & Science in Sports & Exercise, 46(5), 911-919. https://doi.org/10.1249/mss.0000000000000191
Girdler, S. J., Confino, J. E., & Woesner, M. E. (2019). Exercise As a Treatment for Schizophrenia: A Review, 49(1), 56–69. Psychopharmacology Bulletin.
Griwijoyo, S., & Sidik, D. J. (2013). Ilmu Faal Olahraga (Fisiologi Olahraga): Fungsi Tubuh Manusia pada Olahraga untuk Kesehatan dan Prestasi. Bandung: Remaja Rosdakarya
Højman, P., Fjelbye, J., Zerahn, B., Christensen, J., Dethlefsen, C., Lonkvist, C., … & Gehl, J. (2014). Voluntary exercise prevents cisplatin-induced muscle wasting during chemotherapy in mice. Plos One, 9(9), e109030. https://doi.org/10.1371/journal.pone.0109030
Keefe, R. S. E., Poe, M., Walker, T. M., Kang, J. W., & Harvey, P. D. (2006). The Schizophrenia Cognition Rating Scale: An Interview-Based Assessment and Its Relationship to Cognition, Real-World Functioning, and Functional Capacity, 163(3), 426–432. American Journal of Psychiatry.
Kemenkes RI. (2018). Laporan Nasiona Riset Kesehatan Daerah 2018. Badan Penelitian dan Pengembangan Kesehatan.
Kusumawardhani A.A.A.A, Dharmono S, D. H. (2011). Konsensus Penatalaksanaan Gangguan Skizofrenia (Pertama). Perhimpunan Dokter Spesialis Kedokteran Jiwa Indonesia Jakarta (PDSKJI).
Kong, J., Jok, L., Ayub, A., & Bau, R. (2017). Worksite weight management program. Nutrition & Food Science, 47(4), 490-510. https://doi.org/10.1108/nfs-08-2016-0132
Libowitz, M. and Nurmi, E. (2021). The burden of antipsychotic-induced weight gain and metabolic syndrome in children. Frontiers in Psychiatry, 12. https://doi.org/10.3389/fpsyt.2021.623681
Li, L., Li, X., Wyler, S., Chen, X., Wan, R., Arnold, A., & Liu, C. (2021). The atypical antipsychotic risperidone targets hypothalamic melanocortin 4 receptors to cause weight gain. The Journal of Experimental Medicine, 218(7). https://doi.org/10.1084/jem.20202484.
Liu, H., Yu, R., Gao, Y., Li, X., Guan, X., Thomas, K., & Zhang, X. (2022). Antioxidant enzymes and weight gain in drug-naive first-episode schizophrenia patients treated with risperidone for 12 weeks: a prospective longitudinal study. Current Neuropharmacology, 20(9), 1774-1782. https://doi.org/10.2174/1570159x19666210920090547
National Alliance on Mental Illness. (2022). What is Schizophrenia? NAMI: National Alliance on Mental Illness. Diakses dari https://www.nami.org/About-Mental-Illness/Mental-HealthConditions/Schizophrenia.
National Institute of Mental Health. (2022). Schizophrenia. Diakses dari https://www.nimh.nih.gov/health/topics/schizophrenia.
Oka, T., Nishimura, Y., Zang, L., Hirano, M., Shimada, Y., Wang, Z., … & Tanaka, T. (2010). Diet-induced obesity in zebrafish shares common pathophysiological pathways with mammalian obesity. BMC Physiology, 10(1). https://doi.org/10.1186/1472-6793-10-21
Owen, M J et al. (2004). The Molecular Genetics of Schizophrenia: New Findings Promise New Insights, 9(1): 14-27. Molecular Psychiatry. doi:10.1038/sj.mp.4001444
Qiu, Y., Dong, Y., Sun, W., Li, G., Li, M., Zhao, Y., & Li, J. (2023). Metabolic biomarkers of risperidone-induced weight gain in drug-naïve patients with schizophrenia. Frontiers in Psychiatry, 14. https://doi.org/10.3389/fpsyt.2023.1144873
Rahardjo, S., Herdaetha, A., & Sudiyanto, A. (2008). Uji Validitas Schizophrenia Cognitive Rating Scale Versi Indonesia.
Soe, A. (2024). Metabolic effects of risperidone on patients with psychosis in a tertiary care hospital of myanmar. GSC Biological and Pharmaceutical Sciences, 26(3), 183-189. https://doi.org/10.30574/gscbps.2024.26.3.0105
Stahl, S. M. (2013). Stahl’s Essential Psychopharmacology Neuroscientific Basis and Practical Applications (4th ed.). Cambridge University Press.
Stępnicki, P., Kondej, M., & Kaczor, A. A. (2018). Current Concepts and Treatments of Schizophrenia, 23(8). Molecules. https://doi.org/10.3390/molecules23082087.
Viljoen, M., & Roos, J. L. (2020). Physical Exercise and The Patient with Schizophrenia, 49(12): 803-808. Australian Journal of General Practice. doi:10.31128/AJGP-04-20-5384
Wan, X., Zhou, F., Huang, X., Yang, H., Wang, L., Shi, Y., & Lin, S. (2019). Risperidone stimulates food intake and induces body weight gain via the hypothalamic arcuate nucleus 5‐ht2c receptor—npy pathway. CNS Neuroscience & Therapeutics, 26(5), 558-566. https://doi.org/10.1111/cns.13281
Weaver, Samuel R. et al. (2021) Cerebral Hemodynamic and Neurotrophic Factor Responses Are Dependent on the Type of Exercise. Vol. 11. Frontiers in Physiology. doi:10.3389/fphys.2020.609935
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