Growth and Development in Preterm Infants: What is The Long-Term Risk?
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ABSTRACT
Background: Indonesia comes in the fifth for the greatest number of preterm births. Preterm infants may inflict various complication as the result of underdeveloped immunity, affecting their growth and development in the long run until they reach adult phase. Such complications could be prevented through adequate nutrition fulfillment. Purpose: This article aimed to elaborate the characteristics of growth and development of premature babies, long term effect on the development and the impact of immunity and gut health of preterm infants in supporting their growth and development. Methods: References cited in this article were obtained from the latest primary literature within the last 10 years. Discussion: The rate and ability of infants to perform catch-up growth depends on the birth weight and gestation age, at which the lower birth weight and lower gestational age had slower rate. Brain structures that of preterm infants differ compared to the term, and these changes give rise to various clinical outcomes, including long term emotional, behavioral changes, cognitive and executive functioning. Immature immune system in preterm infants reduces the protective ability by innate and adaptive immunity in overcoming pathogens compared to term infants, including gut microbiota prematurity which affects nutrition absorption and growth and development catch up ability. Appropriate and adequate nutrition supplementation has shown beneficial effects in promoting the growth of normal gut flora, which allow better absorption of nutrition and therefore enhancing growth rate and supporting the development of preterm infants. Conclusions: Optimal growth and development of preterm infants are supported by sufficient nutrition supplementation to support the growth of gut microbiota, facilitating the catch-up growth and development of premature infants and immune system maturity.
Badan Penelitian dan Pengembangan Kesehatan. Riset Kesehatan Dasar (RISKESDAS). (2013).
Haas, D. M. Preterm birth. BMJ Clin. Evid. 2011, 1404 (2011).
Natarajan, G. & Shankaran, S. Short- and Long-Term Outcomes of Moderate and Late Preterm Infants. Am. J. Perinatol. 33, 305–317 (2016).
The World Health Organization. WHO recommendations on interventions to improve preterm birth outcomes. www.who.int/reproductivehealth (2015).
McKenzie, B. L., Edmonds, L., Thomson, R., Haszard, J. J. & Houghton, L. A. Nutrition Practices and Predictors of Postnatal Growth in Preterm Infants During Hospitalization: A Longitudinal Study. J. Pediatr. Gastroenterol. Nutr. 66, 312–317 (2018).
Corpeleijn, W. E., Kouwenhoven, S. M. P. & Van Goudoever, J. B. Optimal growth of preterm infants. World Rev. Nutr. Diet. 106, 149–155 (2013).
Leksomono, N., Haksari, E. L. & Sutomo, R. Predictors of early growth failure in preterm, very low birth weight infants during hospitalization. Paediatr. Indones. 59, 44–50 (2014).
Rover, M. M. S., Viera, C. S., Silveira, R. C., Guimarí£es, A. T. B. & Grassiolli, S. Risk factors associated with growth failure in the follow-up of very low birth weight newborns. J. Pediatr. (Rio. J). 92, 307–313 (2016).
Zozaya, C., Díaz, C. & De Pipaón, M. S. How Should We Define Postnatal Growth Restriction in Preterm Infants? Neonatology 114, 177–180 (2018).
Ong, K. et al. Postnatal growth in preterm infants and later health outcomes: a systematic review. Acta Paediatr. 104, 974–986 (2015).
Toftlund, L. H., Halken, S., Agertoft, L. & Zachariassen, G. Catch-Up Growth, Rapid Weight Growth, and Continuous Growth from Birth to 6 Years of Age in Very-Preterm-Born Children. Neonatology 114, 285–293 (2018).
Durá-Travé, T., Martín-García, I. S., Gallinas-Victoriano, F., Chueca-Guindulain, M. J. & Berrade-Zubiri, S. Catch-up growth and associated factors in very low birth weight infants. An. Pediatría (English Ed. 93, 282–288 (2020).
Thompson, D. K. et al. Characterisation of brain volume and microstructure at term-equivalent age in infants born across the gestational age spectrum. NeuroImage Clin. 21, 101630 (2019).
Belfort, M. B. et al. Infant growth before and after term: Effects on neurodevelopment in preterm infants. Pediatrics 128, 899–906 (2011).
Pascoe, M. J., Melzer, T. R., Horwood, L. J., Woodward, L. J. & Darlow, B. A. Altered grey matter volume, perfusion and white matter integrity in very low birthweight adults. NeuroImage Clin. 22, (2019).
Bouyssi-Kobar, M. et al. Third trimester brain growth in preterm infants compared with in utero healthy fetuses. Pediatrics 138, (2016).
Lefèvre, J. et al. Are developmental trajectories of cortical folding comparable between cross-sectional datasets of fetuses and preterm newborns? Cereb. Cortex 26, 3023–3035 (2016).
Brumbaugh, J. E. et al. Altered brain function, structure, and developmental trajectory in children born late preterm. Pediatr. Res. 80, 197–203 (2016).
Taylor, H. G. et al. Brain volumes in adolescents with very low birth weight: Effects on brain structure and associations with neuropsychological outcomes. Dev. Neuropsychol. 36, 96–117 (2011).
de Kieviet, J. F., Zoetebier, L., van Elburg, R. M., Vermeulen, R. J. & Oosterlaan, J. Brain development of very preterm and very low-birthweight children in childhood and adolescence: a meta-analysis. Dev. Med. Child Neurol. 54, 313–323 (2012).
Kidokoro, H. et al. Brain injury and altered brain growth in preterm infants: Predictors and prognosis. Pediatrics 134, (2014).
You, J., Shamsi, B. H., Hao, M., Cao, C.-H. & Yang, W.-Y. A study on the neurodevelopmental outcomes of late preterm infants. BMC Neurol. 19, (2019).
Brossard-Racine, M., du Plessis, A. J. & Limperopoulos, C. Developmental Cerebellar Cognitive Affective Syndrome in Ex-preterm Survivors Following Cerebellar Injury. Cerebellum 14, 151–164 (2015).
Moreira, R. S., Magalhí£es, L. C. & Alves, C. R. L. Effect of preterm birth on motor development, behavior, and school performance of schoola-age children: A systematic review. J. Pediatr. (Rio. J). 90, 119–134 (2014).
Sammallahti, S. et al. Infant growth after preterm birth and neurocognitive abilities in young adulthood. J. Pediatr. 165, 1109-1115.e3 (2014).
Guellec, I. et al. Effect of Intra- and Extrauterine Growth on Long-Term Neurologic Outcomes of Very Preterm Infants. J. Pediatr. 175, 93-99.e1 (2016).
Murray, E. et al. Differential Effect of Intrauterine Growth Restriction on Childhood Neurodevelopment: A Systematic Review. BJOG An Int. J. Obstet. Gynaecol. 122, 1062–1072 (2015).
Ruys, C. A. et al. Early-life growth of preterm infants and its impact on neurodevelopment. Pediatr. Res. 85, 283–292 (2019).
Pampanini, V. et al. Preterm infants with severe extrauterine growth retardation (EUGR) are at high risk of growth impairment during childhood. Eur. J. Pediatr. 174, 33–41 (2014).
de Vries, L. S., Benders, M. J. N. L. & Groenendaal, F. Progress in Neonatal Neurology with a Focus on Neuroimaging in the Preterm Infant. Neuropediatrics 46, 234–241 (2015).
Oudgenoeg-Paz, O., Mulder, H., Jongmans, M. J., van der Ham, I. J. M. & Van der Stigchel, S. The link between motor and cognitive development in children born preterm and/or with low birth weight: A review of current evidence. Neurosci. Biobehav. Rev. 80, 382–393 (2017).
Kieviet, J. F. de et al. A crucial role for white matter alterations in interference control problems of very preterm children. Pediatr. Res. 75, 731–737 (2014).
Bäuml, J. G. et al. The association of children's mathematic abilities with both adults' cognitive abilities and intrinsic fronto-parietal networks is altered in preterm-born individuals. Brain Struct. Funct. 222, 799–812 (2017).
Basten, M., Jaekel, J., Johnson, S., Gilmore, C. & Wolke, D. Preterm Birth and Adult Wealth: Mathematics Skills Count. Psychol. Sci. 26, 1608–1619 (2015).
Cheong, J. L. Y. et al. Contribution of Brain Size to IQ and Educational Underperformance in Extremely Preterm Adolescents. PLoS One 8, (2013).
Kelly, C. E. et al. Working memory training and brain structure and function in extremely preterm or extremely low birth weight children. Hum. Brain Mapp. 41, 684–696 (2020).
Mulder, H., Oudgenoeg-Paz, O., Hellendoorn, A. & Jongmans, M. J. How Children Learn to Discover Their Environment: An Embodied Dynamic Systems Perspective on the Development of Spatial Cognition. Neuropsychol. Sp. Spat. Funct. Hum. Brain 309–360 (2017).
Goyen, T. A., Lui, K. & Hummell, J. Sensorimotor skills associated with motor dysfunction in children born extremely preterm. Early Hum. Dev. 87, 489–493 (2011).
de Jong, M., Verhoeven, M. & van Baar, A. L. School outcome, cognitive functioning, and behaviour problems in moderate and late preterm children and adults: A review. Semin. Fetal Neonatal Med. 17, 163–169 (2012).
Burnett, A. C. et al. Prevalence of psychiatric diagnoses in preterm and full-term children, adolescents and young adults: A meta-analysis. Psychol. Med. 41, 2463–2474 (2011).
Eryigit-Madzwamuse, S., Strauss, V., Baumann, N., Bartmann, P. & Wolke, D. Personality of adults who were born very preterm. Arch. Dis. Child. Fetal Neonatal Ed. 100, F524–F529 (2015).
Nussbaum, C. & Sperandio, M. Innate immune cell recruitment in the fetus and neonate. J. Reprod. Immunol. 90, 74–81 (2011).
Luciano, A. A., Yu, H., Jackson, L. W., Wolfe, L. A. & Bernstein, H. B. Preterm labor and chorioamnionitis are associated with neonatal T cell activation. PLoS One 6, (2011).
Collado, M. C. et al. Factors influencing gastrointestinal tract and microbiota immune interaction in preterm infants. Pediatr. Res. 77, 726–731 (2015).
Olin, A. et al. Stereotypic Immune System Development in Newborn Children. Cell 174, 1277-1292.e14 (2018).
Sharma, A. A., Jen, R., Butler, A. & Lavoie, P. M. The developing human preterm neonatal immune system: A case for more research in this area. Clin. Immunol. 145, 61–68 (2012).
Strunk, T., Currie, A., Richmond, P., Simmer, K. & Burgner, D. Innate immunity in human newborn infants: Prematurity means more than immaturity. J. Matern. Neonatal Med. 24, 25–31 (2011).
Walker, J. C. et al. Development of Lymphocyte Subpopulations in Preterm Infants. Scand. J. Immunol. 73, 53–58 (2011).
Wopereis, H., Oozeer, R., Knipping, K., Belzer, C. & Knol, J. The first thousand days - intestinal microbiology of early life: Establishing a symbiosis. Pediatr. Allergy Immunol. 25, 428–438 (2014).
Tamburini, S., Shen, N., Wu, H. C. & Clemente, J. C. The microbiome in early life: Implications for health outcomes. Nat. Med. 22, 713–722 (2016).
De Leoz, M. L. A. et al. Lacto-N-tetraose, fucosylation, and secretor status are highly variable in human milk oligosaccharides from women delivering preterm. J. Proteome Res. 11, 4662–4672 (2012).
Underwood, M. A. et al. Human milk oligosaccharides in premature infants: Absorption, excretion, and influence on the intestinal microbiota. Pediatr. Res. 78, 670–677 (2015).
Bode, L. Human milk oligosaccharides: Every baby needs a sugar mama. Glycobiology 22, 1147–1162 (2012).
Melville, J. M. & Moss, T. J. M. The immune consequences of preterm birth. Front. Neurosci. 21, 79 (2013).
Henderickx, J. G. E., Zwittink, R. D., Van Lingen, R. A., Knol, J. & Belzer, C. The preterm gut microbiota: An inconspicuous challenge in nutritional neonatal care. Front. Cell. Infect. Microbiol. 9, (2019).
Arboleya, S. et al. Intestinal microbiota and weight-gain in preterm neonates. Front. Microbiol. 8, 183 (2017).
Grier, A. et al. Impact of prematurity and nutrition on the developing gut microbiome and preterm infant growth. Microbiome 5, 158 (2017).
Al-Asmakh, M. & Zadjali, F. Use of germ-free animal models in microbiota-related research. J. Microbiol. Biotechnol. 25, 1583–1588 (2015).
Yu, Y., Lu, L., Sun, J., Petrof, E. O. & Claud, E. C. Preterm infant gut microbiota affects intestinal epithelial development in a humanized microbiome gnotobiotic mouse model. Am. J. Physiol. - Gastrointest. Liver Physiol. 311, G521–G532 (2016).
Yang, I. et al. The infant microbiome: Implications for infant health and neurocognitive development. Nurs. Res. 65, 76–88 (2016).
Gregory, K. E. et al. Influence of maternal breast milk ingestion on acquisition of the intestinal microbiome in preterm infants. Microbiome 4, 68 (2016).
Tirone, C. et al. Gut and Lung Microbiota in Preterm Infants: Immunological Modulation and Implication in Neonatal Outcomes. Front. Immunol. 10, 2910 (2019).
Krajmalnik-Brown, R., Ilhan, Z. E., Kang, D. W. & DiBaise, J. K. Effects of gut microbes on nutrient absorption and energy regulation. Nutr. Clin. Pract. 27, 201–214 (2012).
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