Sustainable Utilization of Grapevine Waste as a Nutraceutical
Pemanfaatan Berkelanjutan Limbah Anggur melalui Uji Fitokimia dan Bioaktivitas untuk Pemakaian Nutraseutik Biji dan Kulit yang Dikeringkan di Bawah Sinar Matahari
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Background: Grape (Vitis vinifera L.), a widely cultivated fruit, generates substantial waste during wine production. Traditionally discarded, this waste was reviewed for various applications, including chemicals, bio-products, and pigments.
Objectives: Sundried seeds (SDS) and peel (SDP) of grapes (Vitis vinifera L.) were investigated for phytochemical composition and potential bioactivity as waste material for potential health benefits.
Methods: Grapevine waste, specifically seeds and peel, was sun-dried and employed for the experimental study with convenient sampling for quantitative analysis. The dried samples were subjected to Fourier-transform infrared (FTIR) spectroscopy to identify primary and secondary metabolites. Ultraviolet-visible (UV-Vis) spectrophotometry was used to quantify specific compounds, including flavonoids, alkaloids, steroids, and phenolic compounds. Antioxidant activity was assessed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay with different solvents (aqueous, ethanolic, and methanolic). Antimicrobial assays were tested against Staphylococcus aureus and Escherichia coli.
Results: Sundried seeds (SDS) and peel (SDP) exhibited respective concentrations of 128 mg/ml and 141 mg/ml for flavonoids, 95 AE/g and 103 AE/g for alkaloids, 10.2 mg/ml and 9.6 mg/ml for steroids, and 170 GAE/g and 187 GAE/g for phenolic compounds.IC50 yield of SDS extracts exhibited in aqueous(5.84 ppm) and methanolic solvents(6.75 ppm), while SDP extracts showed moderate to strong activity in ethanol(47.71ppm) and methanol(84.50 ppm). Staphylococcus aureus inhibited the zone of 9 mm and 10mm and Escherichiacoli ruptured the membrane in 10 mm and 8 mm on both samples.
Conclusions: Sundried seeds and peel from grapevine waste exhibited promising antioxidant and antimicrobial properties, promising further research for potential value-added applications.
Abraham, S., R. Noriega, B. & Shin, J. Y. College students’ eating habits and knowledge of nutritional requirements. Journal of Nutrition and Human Health 02, (2018). DOI:10.35841/nutrition-human-health.2.1.13-17.
Dreßler, M. Sustainable Entrepreneurship: A Guide to Strategic Business Management for Small Entrepreneurs in the Wine Industry and Beyond. (UVK Verlag, 2024). DOI:10.24053/9783739882239.
Peña-Portillo, G.-C., Acuña-Nelson, S.-M. & Bastías-Montes, J.-M. From Waste to Wealth: Exploring the Bioactive Potential of Wine By-Products—A Review. Antioxidants 13, 992 (2024). DOI:10.3390/antiox13080992.
Hanani Ismail, A., Kusbiantoro, A., Tajunnisa, Y., Jaya Ekaputri, J. & Laory, I. A review of aluminosilicate sources from inorganic waste for geopolymer production: Sustainable approach for hydrocarbon waste disposal. Cleaner Materials 13, 100259 (2024). DOI:10.1016/j.clema.2024.100259.
Bandh, S. A., Malla, F. A., Wani, S. A. & Hoang, A. T. Waste Management and Circular Economy. in Waste Management in the Circular Economy 1–17 (Springer International Publishing, Cham, 2023). DOI:10.1007/978-3-031-42426-7_1.
Voss, M. et al. Unlocking the Potential of Agrifood Waste for Sustainable Innovation in Agriculture. Recycling 9, 25 (2024). DOI:10.3390/recycling9020025.
Joshi, H., Joshi, A., Bhandarkar, A. & Chodankar, P. Nutraceuticals: A Potential Source in Treating Human Ailments. in Herbals as Nutraceuticals 69–96 (Apple Academic Press, New York, 2024). DOI:10.1201/9781003488392-6.
Baroi, A. M., Popitiu, M., Fierascu, I., Sărdărescu, I.-D. &Fierascu, R. C. Grapevine Wastes: A Rich Source of Antioxidants and Other Biologically Active Compounds. Antioxidants 11, 393 (2022). DOI:10.3390/antiox11020393.
Ferreyra, S., Bottini, R. & Fontana, A. Background and Perspectives on the Utilization of Canes’ and Bunch Stems’ Residues from Wine Industry as Sources of Bioactive Phenolic Compounds. J Agric Food Chem 71, 8699–8730 (2023). DOI: 10.1021/acs.jafc.3c01635.
Oyenihi, A. B. & Smith, C. Are polyphenol antioxidants at the root of medicinal plant anti-cancer success? J Ethnopharmacol 229, 54–72 (2019). DOI: 10.1016/j.jep.2018.09.037.
Muscolo, A., Mariateresa, O., Giulio, T. & Mariateresa, R. Oxidative Stress: The Role of Antioxidant Phytochemicals in the Prevention and Treatment of Diseases. Int J Mol Sci 25, 3264 (2024). Doi:10.3390/ijms25063264.
Zhang, L.-X. et al. Resveratrol (RV): A pharmacological review and call for further research. Biomedicine & Pharmacotherapy 143, 112164 (2021). DOI: 10.1016/j.biopha.2021.112164.
Jancy Rani D. &VijayanchaliS.S. Phytochemical Composition and Antioxidant Activity of Fresh and Dried Grape (Vitis vinifera) Fruit Proportions. Int J Innov Sci Res Technol 6, (2021).
Suma, A. et al. GCMS and FTIR analysis on the methanolic extract of red Vitis Vinifera seed. World Journal of Pharmaceutical sciences 106–113 (2018).
Akcay, C., Ceylan, F. & Arslan, R. Production of oyster mushroom (Pleurotus ostreatus) from some waste lignocellulosic materials and FTIR characterization of structural changes. Sci Rep 13, 12897 (2023). DOI:10.1038/s41598-023-40200-x.
Bancuta, O.R.et al. FT-IR and UV–Vis characterization of grape extracts used as antioxidants in polymers. Rev. Roum. Chim 60, 571–577 (2015). DOI:10.37358/RC.18.6.6322.
Radulescu, C. et al. Phytochemical Profiles, Antioxidant and Antibacterial Activities of Grape (Vitis vinifera L.) Seeds and Skin from Organic and Conventional Vineyards. Plants 9, 1470 (2020). DOI:10.3390/plants9111470.
Hanaa, M., Elshafie, M., Ismail, H., Mahmoud, M. & Ibrahim, H. Chemical studies and phytochemical screening of grape seeds (Vitis Vinifera L.). Minia J. Agric. Res. 35, 313–325 (2015).
Hassan, Y. I., Kosir, V., Yin, X., Ross, K. & Diarra, M. S. Grape Pomace as a Promising Antimicrobial Alternative in Feed: A Critical Review. J Agric Food Chem 67, 9705–9718 (2019). DOI: 10.1021/acs.jafc.9b02861.
Bushra, K.A., Essa, M.A.& Sabah, M.R. Inhibition of the sea Gene Expression in Staphylococcus aureus Using the Aqueous and Alcoholic Extracts of the Grapevine (Vitis vinifera L.) Seeds. Arch Razi Inst 77, 269–276 (2022). DOI: 10.22092/ARI.2021.356364.1830.
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