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Abstract

Antioxidants are important compounds for the human body because they function to capture free radicals causing degenerative diseases. Flavonoid and phenolic compounds in dates have antioxidant activity that can inhibit the increase in lipid peroxide and protein oxide. This study aims to prove the increase in the concentration of mice (Mus musculus) spermatozoa given ethanol extract dates and exposed to 2-methoxyethanol. Experimental animals used 35 mice (Mus musculus), divided into 5 groups (7 mice per group). The negative control group (K-) was the control group without administration of 2-methoxyethanol and date ethanol extract, the positive control group (K+) was given 200 mg/kg 2-methoxyethanol + CMC 0.5%, the treatment group 1 (P1) was given 200 mg/kg BW 2-methoxyethanol + 3.5 mg/gBW of ethanol extract dates, treatment group 2 (P2) were given 200 mg/kg BW 2-methoxyethanol + 7 mg/gBW of date palm ethanol extract, and treatment group 3 (P3) were given 200 mg/kg 2-methoxyethanol + 10.5 mg/gBW of ethanol extract dates. The results showed there were significant differences in spermatozoa concentrations between the positive control group (K+) and the negative control group (K-), treatment group 1 (P1) and treatment groups 2 and 3. mice (Mus musculus) exposed to 2-methoxyethanol.

Keywords

Ethanol extract of dates 2-methoxyethanol spermatozoa concentration

Article Details

How to Cite
Yassin, T. R., Yaudiwati, R., & I’tishom, R. (2020). Effect of Ethanol Extract of Date Palm Fruit (Phoenix dactylifera. L) on Spermatozoa Concentration of BALB/c Mice (Mus Musculus) Exposed to 2-Methoxyethanol. Folia Medica Indonesiana, 56(2), 82–85. https://doi.org/10.20473/fmi.v56i2.21189

References

  1. Baliga MS, et al (2010). A review of the chemistry and pharmacology of the date fruits (Phoenix dactylifera L). Food Research International, In Press, Accepted Manuscript.
  2. Giwercman A, Bonde JP (1998). Declining male fertility and environmental factors. Endocrinol Metab Clin North Am 27, 807-830
  3. Hamada A, Esteves SC, Agarwal A (2012). Unexplained infertility-looking beyond routine semen analysis. Eur Urol Rev 7, 90-6
  4. Hayati A, Yunaida B, Pidada IBR, Darmanto W, Winarni D (2004). Efek 2-methoxyethanol terhadap Struktur Histologi Mencit (Mus musculus). Penelitian Berkala Hayati 10, 7-12
  5. Starek AK, Miranowicz-Dzierzawska B, Starek-Swiechowicz (2010). Interactive affect of combined exposure to ethylene glycol ethers and ethanolon hematological parametersin rats. Health 2, 1054-1064

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