Article Sidebar

Submitted
28 December 2017
Accepted
28 December 2017
Published
28 December 2017
Download
PDF
Statistic
Read Counter : 4773 Download : 2260

Main Article Content

Abstract

Red dragon fruit skin extract is used as an antioxidant to lead acetate toxicity. This study aimed to prove the difference in morphology of mice testicular spermatozoa exposed to lead acetate. Twenty-five mice were divided into 5 groups (5 mice per group). K- group was the control group without lead acetate and dragon fruit skin extract administration, K + group was treated with 8 mg/KgBW lead acetate administration for 14 days, P1 group was treated with the administration of 8 mg/KgBW lead acetate for 14 days + 250 mg/kgBW red dragon fruit skin extract for 21 days, P2 group was treated with the administration of 8 mg/KgBW lead acetate for 14 days + 500 mg/kgBW red dragon fruit skin extract for 21 days, and group P3 was a treatment group with the administration of 8 mg/KgBW lead acetate for 14 days + 1000 mg/kgBW red dragon fruit extract for 21 days. The results showed that there was significant difference (P<0.05) in normal sperm morphology among K-, K +, P1, P2, and P3. In conclusion, the administration of red dragon skin extract at a dose of 500 mg/kgBW (P2) is the optimal one which can be used as therapy to increase motility, morphology, and concentration of mice spermatozoa exposed to lead acetate.

Keywords

Lead acetate red dragon fruit skin extract spermatozoa motility morphology of spermatozoa

Article Details

License

  • Folia Medica Indonesiana is a scientific peer-reviewed article which freely available to be accessed, downloaded, and used for research purposes. Folia Medica Indonesiana (p-ISSN: 2541-1012; e-ISSN: 2528-2018) is licensed under a Creative Commons Attribution 4.0 International License. Manuscripts submitted to Folia Medica Indonesiana are published under the terms of the Creative Commons License. The terms of the license are:

    Attribution ” You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

    NonCommercial ” You may not use the material for commercial purposes.

    ShareAlike ” If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.

    No additional restrictions ” You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

    You  are free to :

    Share ” copy and redistribute the material in any medium or format.

    Adapt ” remix, transform, and build upon the material.

How to Cite
Raharjo, R., Sudjarwo, S. A., & I’tishom, R. (2017). EFFECTS OF RED DRAGON FRUIT (Hylocereus polyrhizus) SKIN EXTRACT ON LEAD ACETATE TOXICITY IN THE MORPHOLOGY OF Balb/c MICE (Mus musculus) SPERMATOZOA. Folia Medica Indonesiana, 53(4), 237–241. https://doi.org/10.20473/fmi.v53i4.7152
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX

References

  1. Acharya UR, Acharya S, Misrhra (2003). Lead acetate induced cytotocity in male germinal cells of swiss mice, Industrial Health 41, 291-294
  2. Al-Masri SA (2015). Effect of pumpkin oil and vitamin e on lead induced testiscular toxicity in male rats. The Journal of Animal & Plant Sciences 25, 72-77
  3. Al-Shaikh MN, Wahab A, Tala AL, Kareem SHA (2013). Protective effect of chufa tubers (cyperus esculentus) on induction of sperm abnormalities in mice treated with lead acetate. International Journal of Drug development & Research 5, 387-392
  4. Chowdhury AR (2009). Recent advances in heavy metals induced effect on male reproduvtive function-a retrospective. Al Ameen Journal Medicine Science 2, 37-42
  5. Hasan W (2012). Pencegahan keracunan timbal kronis pada pekerja dewasa dengan suplemen kalsium. Makara Kesehatan 16, 1-8
  6. Hotz C, Peerson JM, Brown KH (2003). Suggested lower cutoffs of serum zinc concentrations for assess-ing zinc status: reanalysis of the second national health and nutrition examination survey data (1976-1980). Am Journal Clinical Nutrition 78, 756-764
  7. Iswara RAFW (2010). Pengaruh pemberian ekstrak daun Cyclea barbata L. miers terhadap motilitas sper-matozoa mencit balb/c jantan yang dipapar asam rokok, Artikel Karya Tulis Ilmiah, Denpasar, Uni-versitas Udayana
  8. Kim H, Choi HK, Moon JY, et al (2011). Comparative antioxidant and antiproliferative activities of red and white pitayas and their correlation with flavonoid and polyphenol content. Journal of Food Science 76, C38-45
  9. Laila NN, Shofwati I (2013). Kadar timbal dalam darah dan keluhan kesehatan pada operator wanita SPBU. Jurnal Kesehatan Reproduksi 4, 41-49
  10. Lamando D, Soegianto A, Abadi A, Keman S (2014). Antioxidant effects of sarang semut (Myrmecodia pendans) on the apoptosis of spermtogenic cells of rats exposed to plumbum. Research Journal of Phar-maceutical, Biological and Chemical Sciences 5, 282-294
  11. Lee J, Koo N, Min DB (2004). Reactive oxygen species, aging, and antioxidative nutraceuticals. Compre Rev. in Food Sci. and Food Safety 3, 21-33
  12. Mahawati E (2011). Faktor-faktor resiko paparan tim-bal. Jurnal Visikes 10, 131-138
  13. Makker K, Agarwal A, Sharma R (2009). Oxidative stress & male infertility. Indian J Med Res 129, 357-367
  14. Maryanto D, Mulasari SA, Suryani D (2009). Penurunan kadar emisi gas buang karbon monoksida (CO) dengan penambahan arang aktif pada kendaraan bermotor di Yogyakarta. Kes Mas 3, 198-205
  15. Nurliyana R, Zahir IS, Suleiman KM, Aisyah MR, Rahim KK (2010). Antioxidant study of pulps and peels of dragon fruits: a comparative study. Interna-tional Food Research Journal 17, 367-375
  16. Panggabean PCT, Sylvia S, July I (2008). Efek pajanan timbal terhadap infertilitas pria. JKM 8, 87 – 93
  17. Rangkuti MNS (2004). Kandungan logam berat timbal dalam daun dan kulit kayu tanaman kayu manis (Cinnamomum burmani Bl) pada sisi kiri jalan tol Jagorawi. B i o S MART 6, 143-146
  18. Rong-zhen Z, Dao-wei Z (2013). Oxidative stress and role of natural plant derived antioxidants in animal reproduction. Journal of Inyegrative Agriculture 12, 1826-1838
  19. Sharma R, Garu U (2011). Effects of lead toxicity on developing testes in swiss mice. Universal Journal of Enviromental Research and Technology 1, 390-398
  20. Wang X, Sharma RK, Sikka SC, Thomas AJ, Falcone T, Agarwal A (2003). Oxidarive stress is associated with increased apoptosis leading to spermatozoa DNA damage in patient with male factor infertility. Fertility and Sterility 80, 531-535
  21. Werdhasari A (2014). Peran antioksidan bagi kesehatan. Jurnal Bioetik Medisiana Indonesia 3, 59-68
  22. Wu L, Hsu HW, Chen YC, Chiu CC, Lin YI, Ho JA (2006). Antioxidant and antiproliferative activities of red pitaya. Food Chemistry 95, 319–327
  23. Yulianto RA, Isnaini W, Susanti R (2013). Pengaruh pemberian vitamin E terhadap kualitas sperma tikus putih yang dipapar timbal. Unnes Journal Life Science 2, 92-99

Most read articles by the same author(s)