PENGARUH KONSENTRASI SURFAKTAN TERHADAP KARAKTERISTIK FISIK NANOEMULSI DAN NANOEMULSI GEL KOENZYM Q10

Silvi ayu Wulansari, Ririn Sumiyani, Ni Luh Dewi Aryani

= http://dx.doi.org/10.20473/jkr.v4i2.16164
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Abstract


Coenzyme Q10 is a compound that functions as an antioxidant with a large molecular weight of 863.36 g/mol and has lipophilic properties. This makes coenzyme Q10 need to be formulated to improve the solubility of the material and the delivery system in the skin. This study aims to determine the effect of surfactant variations (a combination of PEG-40 HCO and Span 80) on the physical characteristics of nanoemulsion and nanoemulsion gel preparations. Coenzyme Q10 is formulated using the rice bran oil oil phase with the combination surfactant. This research was made in 3 nanoemulsion formulas  FI, F2, F3 and 3 nanoemulsion gel formulas  F4, F5, F6. Evaluation of physical characteristics is done after 24 hours after the preparation is complete, observations made include organoleptic (shape, color and phase formed), pH, viscosity, droplet size, zeta potential and polydispersity index. The research data were processed statistically using the Kruskal-Wallis analysis and Mann-Whitney follow-up tests. The results showed that the surfactant concentration affected physical characteristics (viscosity, droplet size, zeta potential and polydispersity index) with a significantly different result (p <0.05) but the surfactant concentration did not affect the pH with the results not significantly different (p> 0.05)

Keywords


Koenzym Q10, Rice bran oil, Surfaktan, Nanoemulsi, Nanoemulsi Gel

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References


Bhat, P., and Madhav, S., 2011, A detailed review on nanoemulsion drug delivery system, International Journal of Pharmaceutical Sciences and Research, 2(9), 2292-2298.

Chuacharoen, T., Sehanat P., and Cristina M. S., 2019, Effect of surfactant concentrations on physicochemical properties and functionality of curcumin nanoemulsions under conditions relevant to commercial utilization, Journal Molecules, 24, 2744.

Deapsari, Fani, 2017, Penetration of Ubiquinone (Q10) Nanoemulsion Using Olive Oil Through Rat Skin, International Journal of Pharmaceitical and clinical Research, 9(2), 169-172.

Dizaj, S.M., 2013, Preparation and study of vitamin A palmitate microemulsion drug delivery system and investigation of co-surfactant effect. Journal Of Nanostructure in Chemistry, 3, 59.

Gianeti, M.D., Wagemaker, T.A.L., Seixas, V.C., Maia Campos, P.M.B.G., 2011, The use of nanotechnology in cosmetic formulations: The influence of vehicle in the vitamin a skin penetration. Curr, Nanosci., 8, 526–534.

Guan, Y., Wu, J., Zhong, Q., 2016, Eugenol improves physical and chemical stabilities of nanoemulsions loaded with β-carotene, Food Chem, 194, 787-796.

Haidar, I., Harding, I.H., Bowater, I.C., Eldridge, D.S., Charman, W.N., 2017, The role of lecithin degradation on the pH dependent stability of halofantrine encapsulated fat nano-emulsions, Int. J. Pharm., 528, 524-535.

Kakoty M., Gogoi S.B., 2018, Evaluation of surfactant formulation for EOR in some depleted oil felds of upper Assam. In: Sustainability issues in environmental geotechnics, Springer Nature, Proceedings of the 2nd GeoMEast: international congress and exhibition, 57-75.

Khor, Y.P., Koh, S.P., & Long, K., et al., 2014, A Comparative Study of the Physicochemical Properties of a Virgin Coconut Oil Emulsion and Commercial Food Supplement Emulsions, Journal Molecules, 19, 9187-9202.

Korkmaz, E., Gokche, E., Ozer, 2013, Developement and Evaluation of Coenzym Q10 Loaded Solid Lipid Nanoparticle Hydrogel for Enhanced Dermal Delivery, Acta Pharm, 63, 517-529.

Lucangioli, S., Tripodi, V, 2012, The Importance Of The Formulation In The Effectiveness Of Coenzyme Q10 Supplementation In Mitochondrial Disease Therapy, Der Pharmacia Sinica, 3(4), 406-407.

Pertiwi, R.D., 2016, Uji Aktivitas Antibakteri Formulasi Gel Untuk Sariawan Dari Ekstrak Daun Saga (Abrus Precatorius Linn.) Terhadap Bakteri Staphylococus Aureus. Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan, 2(2), 239-247.

Saifullah, M., Ahsan, A., Shishir, M.R.I., 2016, Production, stability and application of micro- and nanoemulsion in

food production and the food processing industry, In Emulsions; Academic, Press: Cambridge, MA, USA, 405-442.

Sarmah, S., Subrata B.G., Fan X., Annanya A.B., 2019, Characterization and identifcation of the most appropriate nonionic surfactant for enhanced oil recovery. Journal of Petroleum Exploration and Production Technology, 9(34), 383.

Setya, S., Talegaonkar, S., & Rardan, B., 2014, Nanoemulsion Formulation Methods and Stability, 3(2), 2214-2228.

Shanmugam, A., Ashokkumar, M., 2014, Ultrasonic preparation of stable flax seed oil emulsions in dairy systems - physicochemical characterization, Food Hydrocoll, 39, 151–162.

Shoviantari, F., Triatiana, E., and Widji, S., 2017, Skin Penetration of Coenzym Q10 in Nanostricture Lipid Carriers Using Olive Oil and Cetyl Palmitate, International Journal of Pharmaceitical and clinical Research, 9(2), 142-145.

Singh, Thakur Gurjeet, and Sharma, Neha, 2016, Chapter 7 – Nanobiomaterials in cosmetics: current status and future prospects. Nanobiomaterials in Galenic Formulations and Cosmetics, Applications of Nanobiomaterials, 149-174.

Sukandi, C.G., 2017, Karakteristik Fisika-pH dan Stabiltas Nanoemulsi Antiaging. Skripsi. Jurusan Farmasi, Universitas Surabaya.

Tang, S.Y., Manickam, S., Wei, T.K., Nashiru, B., 2012, Formulation development and optimization of a novel Cremophore EL-based nanoemulsion using ultrasound cavitation, Ultrason, Sonochem, 19, 330-345.

Tranggono, R. I., & Latifah, F., 2007, Buku Pegangan Ilmu Pengetahuan Koasmetik. Jakarta : Gramedia Pustaka Utama.

Yani, T.N., Anwar, E., Saputri, F.C., 2016, Formulasi Emulgel yang Mengandung Ekstrak Daun Binahong (Anredera cordifolia (Ten.) Steenis) dan Uji Aktivitasnya terhadap Propionibacterium acnes secara In Vitro, Jurnal Kefarmasian Indonesia, 6(2): 89-97.


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