THE TOTAL LEUKOCYTE COUNT OF ELDERLY PATIENTS CONFIRMED COVID-19 WITH/WITHOUT A VENTILATOR IN A SURABAYA GENERAL HOSPITAL IN 2021

Safira Indah Fitriani; Nur Septia Handayani; Erlinda  Widyastuti; Anita  Kurniati

doi:10.20473/jvhs.V7.I1.2023.55-62

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Safira Indah Fitriani Department of Health, Division of Medical Laboratory Technologist, Faculty of Vocational Studies, Universitas Airlangga, Indonesia https://orcid.org/0009-0003-3838-1873
Nur Septia Handayani
nur.septia.h@vokasi.unair.ac.id
(Sinta ID: 6719101), Department of Health, Division of Medical Laboratory Technologist, Faculty of Vocational Studies, Universitas Airlangga, Indonesia https://orcid.org/0000-0002-4769-9192
Erlinda Widyastuti Department of Health, Division of Medical Laboratory Technologist, Faculty of Vocational Studies, Universitas Airlangga, Indonesia https://orcid.org/0000-0002-5636-1986
Anita Kurniati Department of Health, Division of Medical Laboratory Technologist, Faculty of Vocational Studies, Universitas Airlangga, Indonesia https://orcid.org/0000-0001-9264-5719

Vol. 7 No. 1 (2023): July 2023 | JOURNAL OF VOCATIONAL HEALTH STUDIES

Original Research Article

July 30, 2023

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Background: Coronavirus is a virus that attacks the immune system, especially the human respiratory system. The elderly are at high risk of being infected with Coronavirus Disease-19 (COVID-19), and as they get older, they are at risk of experiencing severe symptoms when infected with COVID-19. Leukocytes play a role in the immune system against foreign objects. The leukocyte count will decrease in the elderly. On the other hand, the increase of leukocytes plays a role as a clinical sign that is useful to be a predictor of body immunity when infected with COVID-19. Purpose: To determine the total leukocyte count in elderly patients that were confirmed COVID-19 and hospitalized with and without a ventilator. Method: This study was a cross-sectional design study involving 93 elderly patients in General Hospital Surabaya. Result: The results showed no difference in the total leukocyte count in elderly hospitalized patients with and without a ventilator (p-value = 0.756). Age above 70 years old increases the risk of patients requiring a ventilator up to 1.7 times compared to patients under 70 years old. The highest leukocyte count was 20.880/mm3, and the lowest was 3.760/mm3. The ratio of leukocyte count in elderly patients with a ventilator group is 1 : 3 for low and high leukocyte counts, respectively. Conclusion: Leukocyte count is an important parameter as the predictor of the progression of the disease and helps in the decision regarding treatment strategy to prevent the cytokine storm.

Fitriani, S. I., Handayani, N. S., Widyastuti, E. ., & Kurniati, A. . (2023). THE TOTAL LEUKOCYTE COUNT OF ELDERLY PATIENTS CONFIRMED COVID-19 WITH/WITHOUT A VENTILATOR IN A SURABAYA GENERAL HOSPITAL IN 2021. Journal of Vocational Health Studies, 7(1), 55–62. https://doi.org/10.20473/jvhs.V7.I1.2023.55-62

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Safira Indah Fitriani, Department of Health, Division of Medical Laboratory Technologist, Faculty of Vocational Studies, Universitas Airlangga, Indonesia

Department of Health, Division of Medical Laboratory Technologist, Faculty of Vocational Studies, Universitas Airlangga, Indonesia

Nur Septia Handayani, (Sinta ID: 6719101), Department of Health, Division of Medical Laboratory Technologist, Faculty of Vocational Studies, Universitas Airlangga, Indonesia

Department of Health, Faculty of Vocational Studies, Universitas Airlangga

Google Scholar Profile: https://scholar.google.co.id/citations?hl=id&user=XkqNUroAAAAJ

Sinta Profile: http://sinta.ristekbrin.go.id/authors/detail?id=6719101&view=overview

Erlinda Widyastuti, Department of Health, Division of Medical Laboratory Technologist, Faculty of Vocational Studies, Universitas Airlangga, Indonesia

Department of Health, Division of Medical Laboratory Technologist, Faculty of Vocational Studies, Universitas Airlangga, Indonesia

Anita Kurniati, Department of Health, Division of Medical Laboratory Technologist, Faculty of Vocational Studies, Universitas Airlangga, Indonesia

Department of Health, Division of Medical Laboratory Technologist, Faculty of Vocational Studies, Universitas Airlangga, Indonesia

Aminzadeh, Z., Parsa, E., 2011. Relationship between Age and Peripheral White Blood Cell Count in Patients with Sepsis. Int. J. Prev. Med. Vol. 2(4), Pp. 238-242.

Andrews, N., Tessier, E., Stowe, J., Gower, C., Kirsebom, F., Simmons, R., Gallagher, E., Thelwall, S., Groves, N., Dabrera, G., Myers, R., Campbell, C.N.J., Amirthalingam, G., Edmunds, M., Zambon,M., Brown, K., Hopkins, S., Chand, M., Ladhani,S.N., Ramsay, M., Bernal, J.L., 2022. Duration ofProtection against Mild and Severe Disease byCovid-19 Vaccines. N. Engl. J. Med. Vol. 386(4), Pp. 340-350.

Anurag, A., Jha, P.K., Kumar, A., 2020. Differential White Blood Cell Count in The COVID-19: A Cross-Sectional Study of 148 Patients. Diabetes Metab. Syndr. Clin. Res. Rev. Vol. 14(6).

Arifin, B., Anas, T., 2021. Lessons Learned from COVID-19 Vaccination in Indonesia: Experiences, Challenges, and Opportunities. Hum. Vaccines Immunother. Vol. 17(11), Pp. 3898–3906.

Baum, U., Poukka, E., Leino, T., Kilpi, T., Nohynek, H., Palmu, A.A., 2022. High Vaccine Effectiveness against Severe Covid-19 in The Elderly in Finland Before and After the Emergence of Omicron. BMC Infect. Dis. Vol. 816.

Belok, S.H., Bosch, N.A., Klings, E.S., Walkey, A.J., 2021. Evaluation of Leukopenia during Sepsis as A Marker of Sepsis-Defining Organ Dysfunction. PLoS One Vol. 16(6), Pp. e0252206.

CDC, 2020. COVID-19 Risks and Vaccine Information for Older Adults.

Dhinata, K.S., 2021. Common Change of Complete Blood Count Parameters in COVID-19: a Literature Review. J.Med. Heal. Vol. 3(2), Pp. 198–207.

Fernandez-Atucha, A., Izagirre, A., Fraile-Bermudez, A.B., Kortajarena, M., Larrinaga, G., Martinez-Lage, P., Echevarría, E., Gil, J., 2017. Sex Differences in The Aging Pattern of Renin-Angiotensin System Serum Peptidases. Biol. Sex Differ. Vol. 8(1), Pp. 1-8.

Ganie, M.S.F., 2020. Hubungan COVID-19 terhadap Masyarakat Lanjut Usia. J. Med. Hutama Vol. 3(1), Pp. 1304–1308.

Gao, Y.-D., Ding, M., Dong, X., Zhang, J.-J., Azkur, A.K., Azkur, D., Gan, H., Sun, Y.-L., Fu, W., Li, W., Liang, H.-L., Cao, Y.-Y., Yan, Q., Cao, C., Gao, H.-Y., Bruggen, M.-C., Veen, W. van de, Sokolowska, M., Akdis, Mu., Akdis, C.A., 2021. Risk Factors for Severe and Critically ill COVID-19 Patients: A Review. Allergy Vol. 76(2), Pp. 428-455.

Gomez-Belda, A.B., Fernandez-Garces, M., Mateo-Sanchis, E., Madrazo, M., Carmona, M., Piles-Roger, L., Artero, A., 2021. COVID-19 in Older Adults: What are The Differences with Younger Patients? Geriatr. Gerontol. Int. Vol. 2(1), Pp.60–65.

Huang, G., Kovalic, A.J., Graber, C.J., 2020. Prognostic Value of Leukocytosis and Lymphopenia for Coronavirus Disease Severity. Emerg. Infect. Dis. Vol. 26(8), Pp. 1839–1841.

Lohmann, K.L., Barton, M.H., 2014. Chapter 11 - Systemic Inflammatory Response Syndrome. Equine Infect. Dis. Second Ed. Pp. 119-131.

Luckheeram, R.V., Zhou, R., Verma, A.D., Xia, B., 2012. CD4 +T cells: Differentiation and functions. Clin. Dev. Immunol.

Mazagatos, C., Monge, S., Olmedo, C., Vega, L., Gallego, P., Martin-Merino, E., Sierra, M.J., Limia, A., Larrauri, A., 2021. Effectiveness of mRNA COVID-19 Vaccines in Preventing SARS-CoV-2 Infections and COVID-19 Hospitalisations and Deaths in Elderly Long-Term Care Facility Residents, Spain, weeks 53 2020 to 13 2021. Eurosurveillance Vol. 26(24), Pp. 1-6.

Ministry of Health Indonesia, 2020. Keputusan Menteri Kesehatan Republik Indonesia Nomor HK.01.07/MenKes/413/2020 Tentang Pedoman Pencegahan dan Pengendalian Corona Virus Disease 2019 (Covid-19), MenKes/413/2020.

Ministry of Health Indonesia, 2021. Profil Kesehatan Indonesia 2020.

Moline, H.L., Whitaker, M., Deng, L., Rhodes, J.C., Milucky, J., Pham, H., Pate, K., Anglin, O., Reingold, A., Chai, S.J., Alden, N.B., Kawasaki, B., Meek, J., Yousey-Hindes, K., Anderson, E.J., Farley, M.M., Ryan, P.A., Kim, S., Nunez, V.T., Como-Sabetti, K., Lynfield, R., Sosin, D.M., McMullen, C., Muse, A., Barney, G., Bennett, N.M., Bushey, S., Shiltz, J., Sutton, M., Abdullah, N., Talbot, H.K., Schaffner, W., Chatelain, R., Ortega, J., Murthy, B.P., Zell, E., Schrag, S.J., Taylor, C., Shang, N., Verani, J.R., Havers, F.P., 2021. Effectiveness of COVID-19 Vaccines in Preventing Hospitalization among Adults Aged >65 Years — COVID-NET. MMWR Recomm. Reports Vol. 70(32), Pp. 1088-1093.

Papadopoulos, V., Li, L., Samplaski, M., 2021. Why Does COVID-19 Kill more Elderly Men Than Women? Is There a Role for Testosterone? Andrology Vol. 9(1), Pp. 65-72.

Pijls, B.G., Jolani, S., Atherley, A., Derckx, R.T., Dijkstra, J.I.R., Franssen, G.H.L., Hendriks, S., Richters, A.,Venemans-Jellema, A., Zalpuri, S., Zeegers, M.P.,2021. Demographic Risk Factors for COVID-19Infection, Severity, ICU Admission and Death: A Meta-Analysis of 59 Studies. BMJ Open Vol. 11(1),Pp. 1-10.