Anthelmintic Activity of Basil Leaves (Ocimum sanctum Linn.) Infusion Against Ascaris suum In Vitro

basil leaves infusion Ascaris suum in vitro

Authors

  • Ogen Sea
    ogen-se-11@fkh.unair.ac.id
    Faculty of Veterinary Medicine, Universitas Airlangga
  • Mas'ud Hariadi Department of Veterinary Reproduction - Faculty of Veterinary Medicine, Universitas Airlangga
  • Setiawan Koesdarto Department of Veterinary Parasitology - Faculty of Veterinary Medicine, Universitas Airlangga
  • muchammad Yunus Department of Veterinary Parasitology - Faculty of Veterinary Medicine, Universitas Airlangga
  • Kusnoto Kusnoto Department of Veterinary Parasitology - Faculty of Veterinary Medicine, Universitas Airlangga
  • Ngakan Made Rai Widjaja Department of Basic Veterinary Medicine - Faculty of Veterinary Medicine, Universitas Airlangga
November 26, 2019

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Ascaris suum is a parasite nematode that causes infection in swines with high prevalence rates in host populations and usually associated with liver damages called “milk spots” caused by larvae migration, resulting in organ condemnation. Basil leaves (Ocimum sanctum) phytochemical constituents contains flavonoid, phenol and tannin. Tannins and phenolics are known to interfere with the energy generation in helminth parasites by uncoupling oxidative phosphorylation and also bind to free proteins in the gastrointestinal tract of host animal or glycoprotein on the cuticle of the parasite and leading to death. This study was aimed to determine the activity of basil leaves (Ocimum sanctum) infusion in several concentrations against A. suum in vitro. This research used six treatments and four replications. This research used 10 A. suum in each treatment with four replication. The observations were done at 12, 18, 24, 30 and 36 hours in an incubator at 37oC. Based on the data analysis, basil leaves (Ocimum sanctum) infusion has anthelmintic activity against A. suum in vitro. The greater of the concentration and the longer of time of immersion, will make the death percentage of A. suum become higher. Concentration of basil leaves (Ocimum sanctum) infusion 15% is the effective concentration that can kill 100% of the A.suum during 36 hours of immersion.

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