Teguh Hari Sucipto, Fahimah Martak

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The human immunodeficiency virus (HIV) is viruses known as rotaviruses. Potential target for therapeutic is reverse transcriptase (RT), possesses an RNA dependent DNA polymerase, DNA-dependent DNA polymerase and ribonuclease H fuctions. Imidazoles have high anti-HIV inhibitory activity, some derivates of imidazole reported drugs. 8-chloro-2,3-dihydroimidazole[1,2-b] [1,4,2]benzodithiazine-5,5-dioxides and 9-chloro-2,3,4-trihydropyri-mido[1,2-b][1,4,2]benzodithi-azine-6,6-dioxides. This compounds succesfully identified anti-HIV activity. Copper is a bio-essential element and copper complexes have been extensively utilized in metal mediated DNA cleavage for the generation of activated oxygen species. It has been reported that teraaza macrocyclic copper coordination compounds have anti-HIV activities. Studies have shown that these macrocyclic complexes can react with DNA in different binding fashions and exhibit effective nuclease activities. Complex compounds are compounds in which there is an atom that acts as the central atom and trotter group of molecules that can be either neutral or charged ions. Application a metal-organic (complex) compounds, especially copper metal and derivates of imidazole. So, in this study can explore new anti-HIV candidate.


Complexes compound; copper; imidazole; antiviral; HIV

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F. Hadizadeh and A. Mehrparvar, Synthesis of Some New 1-[2-alkylthio-1-benzyl-5-imidazolyl) carbonyl]-4-[3-(isopropylamino)-2-pyridyl]piperazine as Anti-HIV, J. Sci. 15 (2004) 131-134

Z. Brzozowski, F. Saczewski, N. Neamati, Synthesis and anti-HIV activity of a novel series of 1,4,2-benzodithiazine-dioxides, Bioorg. Med. Chem. Lett. 16 (2006) 5298

K. Roy and J.T., Leonard, Topological QSAR modeling of cytotoxicity data of anti-HIV 5-phenyl-1-phenylamino-inidazole derivatives using GFA, G/PLS, FA and PCRA techniques, Ind. J. Chem. 45A (2006) 126-137

Y.A. Al-Soud, N.A. Al-Masoudi, H.G. Hassan, E.D. Clercq, C. Pannecouque, Nitroimidazoles. V. Synthesis and anti-HIV evaluation of new 5-substituted piperazinyl-4-nitroimidazole derivatives, Acta Pharm. 57 (2007) 379-393

J. Liu, H. Zhang, C. Chen, H. Deng, T. Lu, L. Ji, Interaction of macrocyclic copper (II) complexes with calf thymus DNA: effects of the side chains of the ligands on the DNA-binding behaviors, Dalton Trans., (2003) 114-119

A. Khan, G. Nicholson, J. Greenman, L. Madden, G. McRobbie, C. Pannecouque, E.D. Clercq, R. Ullom, D.L. Maples, R.L. Maples, J.D. Silversides, T.J. Hubin, S.J. Archibald, Binding optimization through coordination chemistry: CXCR4 chemokine receptor antagonists from ultra rigid metal complexes, J. Am. Chem. Soc. 131 (2009) 3416-3417

T.M. Hunter, L.W. McNae, X. Liang, J. Bella, S. Parsons, M.D. Walkinshaw, P.J. Sadler, Protein recognition of macrocycles: Binding of anti-HIV metallocyclams to lysozyme, PNAS 107 (2005) 2288-2292

E. Maggers, Exploring biologically relevant chemical space with metal complexes, Current Opinion in Chem. Bio. 11 (2007) 287-292

E. Ying, Y. Zheng, H. Zhang, Syntheses, crystal structures and properties of two Cu(II) coordination polymers: Cu(C3N2H4)2(HL)2 and Cu(C3N2H4)2L with C3N2H4=imidazole, H2L=adipic acid, J. Mol. Struc. 93 (2004) 73-80.

G. Liu, X.Wang, H. Zhou, S. Nishihara, Synthesis, structure and magnetic properties of pentanuclear Cu(II) coordination polymer with 4-(imidazole-1-yl)-benzoic acid, Inorg. Chem. Comm. 14 (2011) 1444-1447.

Z. Li, L. Xue, L. Wang, S. Zhang, B. Zhao, Two-dimensional copperbased metal-organic framework as a robust heterogeneous catalyst for the N-arylation of imidazole with arylboronic acids, Inorg. Chem. Comm. 27 (2013) 119-121.

B. Graham, L. Spicca, B.W. Skelton, A.H. White, D.C.R. Hockless, Imidazole derivatives of binuclear copper (II) and Nickel (II) complexes incorporating bis(1,4,7-triazacyclononan-1-yl) ligands, Inorg. Chim. Act. 358 (2005) 3974-3982

Z. Gu, G. Li, P. Yin, Y. Chen, H. Peng, M. Wang, F. Cheng, F. Gu, W. Li, Y. Cai, Temperature-induced two copper (II) supermolecular isomers constructed from 2-ethyl-1H-imidazole-4,5-dicarboxlylate, Inorg. Chem. Comm. 14 (2011) 1479-1484.

S. Das, S. Pal, Self-assembly of copper(II) complexes with a dibasic tridentate ligands and monodentate N-hetrocycles: structural, magnetic and EPR studies, J. Mol. Struc. 741 (2005) 183-192

Y. Song, C. Massera, O. Roubeau, A.M.M. Lanfredi, J. Reedijk, Chloro-bridged Cu(II) pairs linked into a 1D coordination polymer through a dinucleating imidazole-based ligand: 3D structure and magnetism, Polyhedron. 24 (2005) 1599-1605

R. Carballo, A. Castineiras, B. Covelo, E. Martines, J. Niclos, E.M. Lopes, Solid State Coordination Chemistry of Monoclear mixedligand complexes of Ni(II) and Zn(II) with α-hydroxycarboxylic acids and imidazole, Polyhedron. 23 (2004) 1505-1518

A. Pramanik, A. Basu, G. Das, Coordination assembly of p-substituted aryl azo imidazole complexes: influences of electron donating substitution and couter ions, Polyhedron. 29 (2010) 1980-1989

K.K. Sarker, S.S. Halder, D. Banerjee, T.K. Mondal, A.R. Paital, P.K. Nanda, P. Raghvaiah, C. Sinha, Copper-thioarylazoimidazole complexes: Structures, photochromism and redox interconversion between Cu(II) <-> Cu(I) and correlation with DFT calculation, Inorg. Chim. Act. 363 (2010) 2955-2964

M. Beretta, E. Bouwman, L. Casella, B. Douziech, W.L. Driessen, L. Gutierres-Soto, E. Monzani, J. Reedijk, Copper complexes of a new tridentate imidazole-containing ligand: spectroscopy, structures and nitrite reductase reactivity – The molecular stuctures of [Cu(biap)(NO2)2] and [Cu(biap)Br-2], Inorg. Chim. Act. 310 (2000) 41-50


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