PATHOGENESIS OF HEMORRHAGIC DUE TO DENGUE VIRUS

Arief Suseno, Nasronudin Nasronudin

= http://dx.doi.org/10.20473/ijtid.v5i4.2009
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Abstract


Dengue is a viral disease that is mediated by a mosquito, which causes morbidity and mortality. Viruses can increase vascular permeability which can lead to hemorrhagic diathesis or disseminated intravascular coagulation (DIC) known as dengue hemorrhagic fever (DHF). In Indonesia, dengue hemorrhagic fever (DHF) are caused by dengue virus infection which was found to be endemic accompanied by an explosion of extraordinary events that appear at various specified period. The diagnosis of dengue is determined based on the criteria of the World Health Organization (WHO, 1999), which are sudden high fever accompanied by a marked tendency to hemorrhage positive tourniquet test, petechiae, ecchymosis, purpura, mucosal hemorrhagic, hematemesis or melena and thrombocytopenia. The problem that still exists today is the mechanism of thrombocytopenia in patients with varying degrees of dengue involving levels of vWF (von Willebrand factor) and prostaglandin I2 (PGI2) can not be explained. The mechanism of hemorrhagic in dengue virus infections acquired as a result of thrombocytopenia, platelet disfunction decreased coagulation factors, vasculopathy with endothelial injury and disseminated intravascular coagulation (DIC).


Keywords


Hemorrhagic; dengue virus; DHF; criteria; WHO

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References


Price DD, Wilson SR. 2002. Dengue Fever. Available from: http://author.eMedicine.Com/emerg/topic 124.htm Accessed 10/10/2004

Djunaedi D. 2003. Perubahan Kadar Sitokin dan Molekul Agregasi pada Berbagai Tingkat Trombositopenia pada Penyakit Demam Berdarah Dengue. Studi Patobiologis terhadap Prognostikator Perjalanan Penyakit Demam Berdarah Dengue. Disertasi Program Pascasarjana Unair, Surabaya.

WHO. 1999. Strengthening Implementation of the Global Strategy for Dengue Fever/Dengue Haemorhagic Fever Prevention and Control. WHO/CDS/(DEN)/IC/2000. I Engglish only Distr.: Limited.

Eddy Soewandojo. 2002. Tata Laksana Demam Berdarah Dengue pada Orang Dewasa, Seri Penyakit Tropik Infeksi, Perkembangan Terkini dalam Pengelolaan Beberapa Penyakit Tropik Infeksi. Airlangga University Press, hlm. 113–129.

Sutaryo. 2004A. Perkembangan Pathogenesis DBD. Dalam: Demam Berdarah Dengue, Naskah lengkap pelatihan bagi pelatih dokter spesialis anak dan dokter spesialis penyakit dalam dan tata laksana kasus DBD. Penyunting: Hadinegoro SR, Satari HI. Balai Penerbit FKUI, Jakarta, hlm. 32–43.

Sutaryo. 2004B. DENGUE dalam MEDIKA Fakultas Kedokteran Universitas Gadjah Mada Yogyakarta. Edisi pertama.

Nimmannitya S. 1999. Dengue Hemorrhagic Fever: Disorder of Hemostasis. Available from: http://www.ishapd.org/1999/50.pdf Accessed 10/10/2004

Krishnamurti C, Peat RA, Cutting MA, Rothwell SW. 2002. Platelet adhesion to dengue-2 virus-infected endothelial cells. Am J. Trop Med. Hyg: 66(4), pp. 435–441.

Gibbons RV, Vaughn DW. 2002. Dengue: an Escalating Problem. British Med Journal, 324, 1563–1566.3

Suroso T, Umar AI. 2004. Epidemiologi dan Penanggulangan Penyakit DBD di Indonesia saat ini. Dalam: Demam Berdarah Dengue, Naskah lengkap pelatihan bagi pelatih dokter spesialis anak dan dokter spesialis penyakit Dalam dan tata laksana kasus DBD. Penyunting: Hadinegoro SR, Satari HI. Balai Penerbit FKUI, Jakarta, hlm. 14–31.

WHO. 2004. Dengue Fever in Indonesia. Available from: http://

www.WHO. Int/CSR/don/2004-4-08 Accessed 08/04/2004

Shope RE. 2004. Introduction to hemorrhagic fever viruses; hemorrhagic fever caused by Dengue viruses. In: Cecil Textbook of Medicine. Goldman L, Ausiello D (eds). 22nd ed, Saunders, Philadelphia, pp. 2023–2034.

O’Neil SP, Shieh WJ, Zaki SR. 2002. Pathology and Pathogenesis of Virus Infection in Immunology of Infectious Diseases. Kausfmann SH, Sher A, Ahmed R (eds). ASM Press, Washington, pp. 307–323.

Gubler DJ. 1998. Dengue and Dengue Hemorrhagic Fever. Clin Microbiol Reviews,11(3), 480–496.

Djajadiman G. 2004. Perubahan Hematologi pada infeksi Dengue. Dalam: Demam Berdarah Dengue, Naskah lengkap pelatihan bagi pelatih dokter spesialis anak dan dokter spesialis penyakit dalam dan tatalaksana kasus DBD. Penyunting: Hadinegoro SR, Satari HI. Balai Penerbit FKUI, Jakarta, hlm. 44–54.

Lei HY, Yeh TM, Liu HS, et al. 2001. Immunopathogenesis of Dengue Virus Infection. J Biomed Sci, 8, 877–388.

Funahara Y, Ogawa K, Fujita N, Okuno Y. 1987. Three possible triggers to induce thrombocytopenia in dengue virus infection. Sautheast Asian J Trop Med Public Health. 1987 Sep; 18(3): 3515.

Abbas AK, Lichtman AH and Pillai S. 2007. Cellular and Molecular Immunology. 6th Ed. Saunders Elsevier, 2007.

Nawroth PP, Bank I, Handley D, Cassimetris J, Ckess L, Stern D. 1986. Tumor necrosis factor/cachetin interacts with endothelial cell receptors to induce release of interleukin I. J Exp Med 163: 1363–1375.

De Geest, B., Zhao, Z., Collen, D., and Holvoet, P. 1997. Effects of adenovirus-mediated human apo A-l gne transfer on neointima formation after endothelial denudation in apo E-deficient mice. Circulation 96, 4349–4356.

Mauro, V.P., Krushel, L.A., Cunningham, B.A., and Edelman, G.E. 1992. J. Cell Biol. 119, 191–202.

Mitrakul C. 1987. Bleeding problem in dengue haemorrhagic fever:

platelets and coagulation changes. Southeast Asian J Trop Med Pub Hlth 18: 407–412.

Krishnamurti C, Kalayanarooj S, Cutting MA, Peat RA, Rothwell SW, et al. 2001. Mechanism of Haemorrhage in Dengue without Circulatory Collapse. Am J Trop Med. Hyg 65(6), 840–847.

Sugianto D, Tatang K. Samsi, Hansa Wulur, Sefanya A. Dirgagunarsa, G.B. Jennings. 1993. Perubahan Jumlah Trombosit pada Demam Berdarah Dengue. UPF/Lab. Ilmu Kesehatan Anak FK Untar/RS.

Sumber Waras, Jakarta.KONAS Ilmu Kesehatan Anak Ke IX, Semarang.

Franchini G, Ambinder RF, Barry M. 2000.Viral Disease in Hematology. American Society of Hematology, 409–422.


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