MICRONUTRIENT THERAPY FOR SEPSIS
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Micronutrients are nutrients which are needed by the body to perform the function of body. The amounts is less than 100% μg per day and consist of vitamins and minerals. It cannot be synthesized in the body. Research in the US mentioned that the rate prevalence of sepsis is tended to be increased 8.7 % annually. In sepsis, nutrition is one of the important component which could drive the success treatment. Micronutrient, especially a vitamin which is soluble in fats, it would be toxic if the number exceed the capability of body to receive it. Although there are guidance and mutual agreement about sepsis using, it still need to concern on micronutrient which potentially giving bad effect. In sepsis case, micronutrients also determine the success of treatment due to redistribution of vitamin and trace element from circulation to the tissue which involved in the proteins formation and immune system. The conclusions of the latest 7 experiments and 4 random controlled studies of multi-centre support the micronutrients supplementation because it can decrease mortality rate. However, it still need to be aware to the toxicity of fat soluble micronutrient if the doses are excessive.
Visser, 2010. Micronutrients: do small things matter?. South African J Clin Nutr. 23(1), Supplement:S58-S61.
Ozmen M, 2010. Micronutrients in Critically Ill Surgical Patients. European Jurnal of Surgical Sciences, 1(3):86-89.
Djurkovic S, Baracaldo J, Guerra J, 2010. A survey of clinicians addressing the approach to the management of severe sepsis and septic shock in the United States. Journal of Critical Care, 25:658.e1–658.e6.
Hammarqvist, Wernerman, Simon, 2009. Basics in clinical nutrition: Injury and sepsis – The neuroendocrine response. The European e Journal of Clinical Nutrition and Metabolism, 4e4–e6.
Ukleja A, 2010. Altered GI Motility in Critically Ill Patients: Current Understanding of Pathophysiology. Clinical Impact and Diagnostic Approach.
Shenkin A, 2005. The Key Role of Micronutrients. Clinical Nutrition, 25:1-13.
Agarwal A, Khana P, Baidya D, Arora Met, 2011. Trace Elements in Criticall Illness. Journal of Endocrinology and Metabolism, 2(1):57-63.
Crouser E, Exline M, Knoel D, Wewers M, 2008. Sepsis: Links between Pathogen Sensing and Organ Damage. Current Pharmaceutical Design, 14:1840-1852.
Stapleton, Renee. 2010. Zinc Therapy in Criticall Illness. University of Vermont.
Strachnan S, 2010. Trace elements. Current Anaesthesia & Critical Care, 21:44-48.
Braunschweig C, Sowers M, Kovacevich D, 1997. Parenteral Zinc Supplementation in Adult Humans during the Acute Phase Response Increases the Febrile Response. The Journal of Nutrition, 127:70-74.
Doherty P, Weaver L, Prentice A, 2002. Micronutrient Supplementation and Infection: A Double-Edge Sword?. Journal of Pediatric Gastroenterology and Nutrition, 34: 346-352.
Zager R, Johnson A, Hanson S, 2004. Parenteral iron therapy exacerbates experimental sepsis. Kidney International, 65:2108–2112.
S Afr J Clin Nutr, 2010. South African Journal of Clinical Nutrition. 23(1)
Forceville X, 2007. Effect of High Doses Selenium As Sodium Selenite in Septic Shock Patients A Placebo-controlled, Randomized, Double Blind, Multi-center Phase II Study of Selenium and Sepsis. Journal of Trace Element in Medicine and Biology, 21:62-65.
Valenta J, Brodska H, Drabek T, 2010. High-dose Selenium Substitution in Sepsis: A Prospective Randomized Clinical Trial. Intensive Care Med. DOI 10.1007/s00134-011-2153-0.
Roberts A, Bar-Oy D, Winkler J, Rael L, 2003. Copper-induced Oxidation of Epinephrine: Protective Effect of D-DHAK, a Synthetic Analogue of the High Affinity Copper Binding Site of Human Albumin. Biochemichal and Biophysical Research Communication, 304:755-757.
Kalokerinos A, Dettman I, Meakin C, 2005. Endotoxin and Vitamin C Part 1 – Sepsis, Endotoxin and Vitamin C. J. Aust. Coll. Nutr. & Env. Med, 24(1):17-21.
Donnino M, Carney E, Cocchi M, Barbash I, Chase M, Joyce Ne, 2010. Thiamine Deficiency in Critically Ill Patients with Sepsis. Journal of critical care, 25:576-581.
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