Trend and Correlation Between the Scope of Tuberculosis Preventive Therapy (TPT) and Treatment Success Rate (TSR) with the Case Notification Rate (CNR) of Tuberculosis in Indonesia During 2021-2023

Downloads
Background: Tuberculosis remains a major public health problem in Indonesian. The Indonesian TB control program for the 2020–2024 period aims to accelerate the achievement of national TB elimination by 2030 and contribute to ending the global TB epidemic by 2050, aligning with the WHO's End TB Strategy. As part of this national strategy, the government has implemented various interventions, including the provision of Tuberculosis Preventive Therapy (TPT) to high-risk groups and improvements in the Treatment Success Rate (TSR).
Objectives: This research aims to analyze the trends and the correlation between TPT and TSR with the incidence of tuberculosis, measured through the Case Notification Rate (CNR) at the provincial level during 2021-2023.
Methods: This research is an ecological study using quantitative methods. The data in this research are based on tuberculosis prevention reports from the Directorate of Disease Prevention and Control, Ministry of Health of Indonesia, from 2021 to 2023. The variables analyzed in this research are TPT coverage and TSR with CNR in 2021-2023.
Results: The study results show an increasing trend in CNR in Indonesian provinces for three consecutive years. Furthermore, TPT coverage has also increased, although it remains relatively low, and TSR shows variation across provinces. Spearman's analysis indicates a correlation between TPT, TSR, and CNR. However, the correlations are weak and mostly negative.
Conclusion: TPT coverage and TSR in Indonesia showed improvement during 2021–2023, although disparities remained between provinces. The weak correlations between TPT, TSR, and incidence rates indicate that prevention and treatment interventions have not yet fully impacted the reduction of new cases. Strengthening case detection, enhancing contact tracing, and expanding TPT are needed to accelerate the decline in TB incidence nationally.
Alsdurf, H. et al. (2016) “The cascade of care in diagnosis and treatment of latent tuberculosis infection: a systematic review and meta-analysis,” The Lancet: Infectious Disease [Preprint].
Chakaya, J. et al. (2022) “The WHO Global Tuberculosis 2021 Report – not so good news and turning the tide back to End TB,” International Journal of Infectious Diseases, 124, pp. S26–S29. Available at: https://doi.org/10.1016/j.ijid.2022.03.011.
Cristea, V. et al. (2023) “Monitoring the progress achieved towards ending tuberculosis in the European Union/European Economic Area, 2018 to 2021,” Eurosurveillance, 28(12). Available at: https://doi.org/10.2807/1560-7917.ES.2023.28.12.2300154.
Ereso, B.M. et al. (2020) “Barriers for tuberculosis case finding in Southwest Ethiopia: A qualitative study.,” PloS one, 15(1), p. e0226307. Available at: https://doi.org/10.1371/journal.pone.0226307.
Gebremariam, M.K., Bjune, G.A. and Frich, J.C. (2010) “Barriers and facilitators of adherence to TB treatment in patients on concomitant TB and HIV treatment: a qualitative study.,” BMC public health, 10, p. 651. Available at: https://doi.org/10.1186/1471-2458-10-651.
Gebreweld, F.H. et al. (2018) “Factors influencing adherence to tuberculosis treatment in Asmara, Eritrea: a qualitative study.,” Journal of health, population, and nutrition, 37(1), p. 1. Available at: https://doi.org/10.1186/s41043-017-0132-y.
Gebreyohannes, E.A. et al. (2024) “Impacts of armed conflicts on tuberculosis burden and treatment outcomes: a systematic review,” BMJ Open, 14(3), p. e080978. Available at: https://doi.org/10.1136/bmjopen-2023-080978.
Htet, K.K.K. et al. (2018) “Improving detection of tuberculosis among household contacts of index tuberculosis patients by an integrated approach in Myanmar: a cross-sectional study,” BMC Infectious Diseases, 18(1), p. 660. Available at: https://doi.org/10.1186/s12879-018-3586-7.
Kwan, M.-P. (2018) “The Neighborhood Effect Averaging Problem (NEAP): An Elusive Confounder of the Neighborhood Effect,” International Journal of Environmental Research and Public Health, 15(9), p. 1841. Available at: https://doi.org/10.3390/ijerph15091841.
Kementerian Kesehatan Republik Indonesia. (2020). National Action Plan for Tuberculosis Elimination 2020–2024. Ministry of Health of the Republic of Indonesia. https://tbindonesia.or.id/
Kementerian Kesehatan Republik Indonesia. (2021a). National Guidelines for Tuberculosis Control. Ministry of Health of the Republic of Indonesia. https://tbindonesia.or.id/
Kementerian Kesehatan Republik Indonesia. (2021b). Technical Guidelines for Tuberculosis Preventive Therapy (TPT). Ministry of Health of the Republic of Indonesia. https://tbindonesia.or.id/
Kementerian Kesehatan Republik Indonesia. (2023). Indonesia Tuberculosis Dashboard. Ministry of Health of the Republic of Indonesia. https://tbindonesia.or.id/dashboard/
Mhimbira, F.A. et al. (2017) “Interventions to increase tuberculosis case detection at primary healthcare or community-level services.,” The Cochrane database of systematic reviews, 11(11), p. CD011432. Available at: https://doi.org/10.1002/14651858.CD011432.pub2.
Ministry of Health Republic of Indonesia (2022) Report on the Prevention Program Tuberculosis 2021, Ministry of Health of the Republic of Indonesia. Available at: https://tbindonesia.or.id/pustaka_tbc/laporan-tahunan-program-tbc-2021/.
Ministry of Health Republic Indonesia, DJP and P. (2023) Report on the Disease Control Program Tuberculosis 2022, Ministry of Health of the Republic of Indonesia. Available at: https://tbindonesia.or.id/pustaka_tbc/laporan-tahunan-program-tbc-2021/
Ministry of Health Republic of Indonesia (2024) Report on the Disease Control Program Tuberculosis 2023.
N, N. and I, M. (2021) “Mapping TB Case Notification Rate (CNR) by Province in Indonesia,” Epidemiology International Journal, 5(4). Available at: https://doi.org/10.23880/EIJ-16000216.
Reid, M.J.A. et al. (2019) “Building a tuberculosis-free world: The Lancet Commission on tuberculosis,” The Lancet, 393(10178), pp. 1331–1384. Available at: https://doi.org/10.1016/S0140-6736(19)30024-8.
United Nations. (2023). The Sustainable Development Goals Report 2023. United Nations. https://unstats.un.org/sdgs/report/2023/
Villalva-Serra, K. et al. (2025) “Impact of strategic public health interventions to reduce tuberculosis incidence in Brazil: a Bayesian structural time-series scenario analysis,” The Lancet Regional Health - Americas, 41, p. 100963. Available at: https://doi.org/10.1016/j.lana.2024.100963.
World Health Organization. (2015). The End TB Strategy. World Health Organization. https://www.who.int/publications/i/item/9789241509384
WHO (2022) Global tuberculosis report 2022. Available at: http://dx.doi.org/10.1016/j.bpj.2015.06.056%0Ahttps://academic.oup.com/bioinformatics/articleabstract/34/13/2201/4852827%0Ainternalpdf://semisupervised3254828305/semisupervised.ppt%0Ahttp://dx.doi.org/10.1016/j.str.2013.02.005%0Ahttp://dx.doi.org/10.10
World Health Organization. (2020). Latent tuberculosis infection: Updated and consolidated guidelines for programmatic management. World Health Organization. https://www.who.int/publications/i/item/9789240001506
World Health Organization. (2023). Global tuberculosis report 2023. World Health Organization. https://www.who.int/teams/global-tuberculosis-programme/tb-reports
Zenner, D. et al. (2017) “Treatment of Latent Tuberculosis Infection,” Annals of Internal Medicine, 167(4), pp. 248–255. Available at: https://doi.org/10.7326/M17-0609.
Copyright (c) 2025 Nur Baiti, Chatarina Umbul Wahjuni, Kurnia Dwi Artanti

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Media Gizi Kesmas by Unair is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
1. The journal allows the author(s) to hold the copyright and to retain the publishing right of the article without restrictions.
2. The legal formal aspect of journal publication accessibility refers to Creative Commons Attribution-Share-Alike (CC BY-SA).
3. The Creative Commons Attribution-Share-Alike (CC BY-SA) license allows re-distribution and re-use of a licensed work on the conditions that the creator is appropriately credited and that any derivative work is made available under "the same, similar or a compatible license”. Other than the conditions mentioned above, the editorial board is not responsible for copyright violations.
















