Correlation between Vitamin D Levels and Completion of COVID-19 Vaccines with Recurrent COVID-19 Infections in Lecturers at the University of Malahayati
Hubungan Kadar Vitamin D dan Kelengkapan Vaksin COVID-19 dengan Kejadian Infeksi COVID-19 Berulang pada Dosen Universitas Malahayati
Downloads
Background: There is a continued increase in the fatality rate of COVID-19 pandemic despite the apparent containment of the virus. In September 2022, the death toll from this disease has exceeded 150 thousand individuals. Furthermore, Vitamin D has been observed for its correlation with the immune system.
Objectives: This study aimed to analyze correlation between blood vitamin D levels, completeness of COVID-19 vaccine, and compliance with health protocols for recurrent infection.
Methods: This analytical observational study with a cross-sectional method examined correlation between blood vitamin D levels, vaccine completeness status, as well as compliance with health protocols, age, and gender. The population consisted of 62 lecturers at Malahayati University, Bandar Lampung, who were willing to volunteer as subjects. The method used was non-probability sampling and the inclusion criteria were individuals infected with COVID-19 in 2022, resulting in 47 samples. The collected data was analyzed using the chi-square test and logistic regression test.
Results: The results showed that there was a significant correlation between the completeness status of COVID-19 vaccine (p-value=0.001) with an OR of 8.24 and 8.47, as well as low levels of vitamin D in the blood (p-value=0.007) and recurrent infection.
Conclusions: The possibility of recurrent COVID-19 infection was increased when there were lower levels of vitamin D in the bloodstream and a less comprehensive response to vaccine.
Kementrian Kesehatan Republik Indonesia. Infeksi Emerging: COVID 19. Direktorat Jenderal Pencegahan dan Pengendalian Penyakit (2022). Available at: https://infeksiemerging.kemkes.go.id/dashboard/COVID-19.
Farmawati, C., Ula, M. & Qomariyah, Q. Prevention of COVID-19 by Strengthening Body's Immune System through Self-Healing. Populasi 28, 70 (2021).
Hermawan, D. Sehat Selalu dengan Vitamin D. (Penerbit Buku Andi, 2016).
Hermawan, D. Manfaat Vitamin D pada Era Pandemi COVID-19. (Penerbit Buku Andi, 2021).
Trivedi, G. Y. & Saboo, B. The Risk Factors for Immune System Impairment and the Need for Lifestyle Changes. J. Soc. Heal. Diabetes 8, 025–028 (2020).
Manousaki, D. & Richards, J. B. Low vitamin D levels as a risk factor for cancer. BMJ 359, j4952 (2017).
Sigmund, C. D. Regulation of renin expression and blood pressure by vitamin D3. J. Clin. Invest. 110, 155–156 (2002).
Maruotti, N. & Cantatore, F. P. Vitamin D and the immune system. J. Rheumatol. 37, 491–495 (2010).
Vanlint, S. Vitamin D and obesity. Nutrients 5, 949–956 (2013).
Michael F. Holick, M. The Vitamin D Deficiency Pandemic: a Forgotten Hormone Important for Health. Public Health Rev. 32, 267–283 (2010).
Ali, N. Role of vitamin D in preventing COVID-19 infection, progression and severity. J. Infect. Public Health 13, 1373–1380 (2020).
Saluy, P. M., Langingi, N. L. & Kaparang, G. F. Sunbathing as Caring for COVID-19 Patients : A Literature Review. 08, 2397–2408 (2022).
Prietl, B., Treiber, G., Pieber, T. R. & Amrein, K. Vitamin D and immune function. Nutrients 5, 2502–2521 (2013).
Bui, L., Zhu, Z., Hawkins, S., Cortez-Resendiz, A. & Bellon, A. Vitamin D regulation of the immune system and its implications for COVID-19: A mini-review. SAGE Open Med. 9, 205031212110140 (2021).
Panfili, F. M. et al. Possible role of vitamin D in COVID-19 infection in pediatric population. J. Endocrinol. Invest. 44, 27–35 (2021).
Sharun, K., Tiwari, R. & Dhama, K. COVID-19 and sunlight: Impact on SARS-CoV-2 transmissibility, morbidity, and mortality. Ann. Med. Surg. 66, 17–20 (2021).
Tim Komunikasi Komite Penanganan Corona Virus Disease 2019 (COVID-19) dan Pemulihan Ekonomi Nasional. Risiko Kematian COVID-19 Dipengaruhi Usia Dan Riwayat Komorbid. covid19.go.id (2020). Available at: https://covid19.go.id/p/berita/risiko-kematian-COVID-19-dipengaruhi-usia-dan-riwayat-komorbid.
Burhan, E. et al. Pedoman Penatalaksanaan COVID-19 Edisi 4. Pedoman tatalaksana COVID-19 edisi 4 (2022).
Ciarambino, T., Para, O. & Giordano, M. Immune system and COVID-19 by sex differences and age. Women's Heal. 17, (2021).
Abate, B. B., Kassie, A. M., Kassaw, M. W., Aragie, T. G. & Masresha, S. A. Sex difference in coronavirus disease (COVID-19): A systematic review and meta-analysis. BMJ Open 10, 1–10 (2020).
Perrotta, F. et al. COVID-19 and the elderly: insights into pathogenesis and clinical decision-making. Aging Clin. Exp. Res. 32, 1599–1608 (2020).
Hataikarn Nimitphong & Michael F.Holick. Prevalence of Vitamin D Deficiency in Asia Vitamin D status and sun exposure in Southeast Asia. Dermatoendocrinol. 5, 34–37 (2013).
Hermawan, D. & Widodo, S. Kadar 25(OH)D3 darah pada penderita obesitas. J. Gizi Klin. Indones. 18, 1 (2021).
Hermawan, D. & Andoko. Hubungan Antara Kadar Vitamin D dalam Darah dengan Tekanan Darah Usia Lanjut di Natar Lampung Selatan. J. Keperawatan Sriwij. 6, 1–8 (2019).
Herlambang, Nyimas Natasha Ayu Safira, Amelia Dwi Fitri, A. P. Gambaran Kadar Vitamin D Pada Wanita Usia Subur Model Kebijakan Kesehatan Reproduksi. Medic 4, 269–273 (2021).
Herlambang, H. et al. Skrining Kadar Vitamin D Ibu Hamil Di Wilayah Kerja Puskesmas Tahtul Yaman Kota Jambi. Medic 5, 440–444 (2022).
Abeya, S. G. et al. Adherence to COVID-19 preventive measures and associated factors in the Oromia regional state of Ethiopia. PLoS One 16, 1–26 (2021).
Killeit, U. Vitamin D status and COVID-19 . Dtsch. Leb. 118, 1–6 (2022).
Chirumbolo, S., Bjí¸rklund, G., Sboarina, A. & Vella, A. The Role of Vitamin D in the Immune System as a Pro-survival Molecule. Clin. Ther. 39, 894–916 (2017).
Kementrian Kesehatan Republik Indonesia. Vaksinasi COVID-19 Nasional. Kementerian Kesehatan Republik Indonesia (2022). Available at: https://vaksin.kemkes.go.id/#/vaccines.
Doerre, A. & Doblhammer, G. The influence of gender on COVID-19 infection and mortality in Germany: Insights from age- and gender-specific modeling of contact rates, infection, and deaths in the early phase of the pandemic. PLoS One 17, 1–20 (2022).
Freund, O. et al. Associations of vaccine status with characteristics and outcomes of hospitalized severe COVID-19 patients in the booster era. PLoS One 17, 1–12 (2022).
Ng, O. T. et al. Analysis of COVID-19 Incidence and Severity Among Adults Vaccinated With 2-Dose mRNA COVID-19 or Inactivated SARS-CoV-2 Vaccines With and Without Boosters in Singapore. JAMA Netw. open 5, e2228900 (2022).
COVID-19, S. T. P. Capaian Vaksinasi COVID-19 di luar Jawa Bali Masih Rendah. covid.go.id (2022). Available at: https://covid19.go.id/id/artikel/2022/07/02/capaian-vaksinasi-COVID-19-di-luar-jawa-bali-masih-rendah. (Accessed: 30th July 2022)
Statsenko, Y. et al. Impact of Age and Sex on COVID-19 Severity Assessed From Radiologic and Clinical Findings. Front. Cell. Infect. Microbiol. 11, (2022).
De Rui, M. et al. Vitamin D deficiency and leisure time activities in the elderly: Are all pastimes the same? PLoS One 9, (2014).
Hall, J. E. Guyton, and Hall review physiology. (Sauders-Elsevier, 2015).
Hermawan, D. & Hidayat, N. A. Pengaruh paparan sinar matahari pada penderita diabetes melitus tipe 2. Holistik J. Kesehat. 16, 35–41 (2022).
Kusumastuty, I. et al. Hubungan Paparan Sinar Matahari, Status Gizi, dan Asupan Makan terhadap Kadar Vitamin D Anak dan Remaja Penderita Diabetes Mellitus Tipe 1. Amerta Nutr. 5, 41 (2021).
Copyright (c) 2024 Amerta Nutrition
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
AMERTA NUTR by Unair is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
1. The journal allows the author to hold the copyright of the article without restrictions.
2. The journal allows the author(s) to retain publishing rights without restrictions
3. The legal formal aspect of journal publication accessibility refers to Creative Commons Attribution Share-Alike (CC BY-SA).
4. The Creative Commons Attribution Share-Alike (CC BY-SA) license allows re-distribution and re-use of a licensed work on the conditions that the creator is appropriately credited and that any derivative work is made available under "the same, similar or a compatible license”. Other than the conditions mentioned above, the editorial board is not responsible for copyright violation.