Moringa oleifera, Cyclea barbata, Centella asiatica Leaves Extract Intervention Ability to Improve Fetus Development and Blood Protein Levels in Malnutrition Pregnant Model Mice
Intervensi Ekstrak Daun Moringa oleifera, Cyclea barbata, Centella asiatica untuk Meningkatkan Perkembangan Fetus dan Kadar Protein Darah pada Model Mencit Bunting dengan Malnutrisi
Downloads
Background: Pregnant women experiencing chronic energy deficiency are at risk of giving birth to low birth weight and premature (stunted) babies.
Objectives: In an effort to prevent stunting, the study investigates the effects of a 1:1:1 ratio of Moringa oleifera, Cyclea barbata, and Centella asiatica leaf extract on fetal growth and blood protein levels.
Methods: This research used a laboratory experimental approach with 25 adult female Mus musculus Balb/C mice as a model of malnourished pregnancy, was divided into 5 groups: pre-test, positive control, negative control, placebo and test group. Moringa oleifera, Cyclea barbata, and Centella asiatica leaf extracts are administered to the test group and positive control in 1:1:1 ratio.
Results: The study results indicated that in pregnant mice without malnutrition receiving a mixture of Moringa oleifera, Cyclea barbata, and Centella asiatica leaf extracts, the average fetal body length was 9.7% higher and their weight was 7.4% heavier than pregnant mice with experiencing chronic energy deficiency.
Conclusions: The administration of Moringa oleifera, Cyclea barbata, and Centella asiatica leaf extract can contribute to improving fetal development and blood protein levels. However, its effectiveness is more pronounced in normal pregnancies than in pregnancies with chronic energy deficiency as it can prevent stunting.
Masan, L., Haryanti, Y. & Juliansyah, E. Riwayat Ibu Bersalin Kekurangan Energi Kronik Berhubungan dengan Kejadian Bayi Berat Lahir Rendah. J. Sains Kebidanan 4, 7–13 (2022).
Tshotetsi, L., Dzikiti, L., Hajison, P. & Feresu, S. Maternal factors contributing to low birth weight deliveries in Tshwane District, South Africa. PLoS One 14, e0213058 (2019).
Intan Fazrin., L. F. Family Motivation In The Provision Of Nutrition With Stunting Events In Tons Of Together In Pujiharjo Village, Tirtoyudo District. J. Glob. Res. Public Heal. 6, 56–65 (2021).
Harskamp-van Ginkel, M. W. et al. Potential determinants during ‘the first 1000 days of life’ of sleep problems in school-aged children. Sleep Med. 69, 135–144 (2020).
Safarringga, A. & Putri, R. D. Pengaruh pemberian ekstrak daun kelor terhadap produksi asi pada ibu nifas. J. Trop. Med. Issues 1, 9–15 (2021).
Johan, H., Anggraini, R. D. & Noorbaya, S. Potensi Minuman Daun Kelor Terhadap Peningkatan Produksi Air Susu Ibu (ASI) Pada Ibu Postpartum. Sebatik 23, 192–194 (2019).
Dr.Ari Wibowo, Dr.dr. Moch Yuus, Septa Katmawatnti, A. S. Tepung Daun Kelor, Glutamin, Dan Glukosa Unhidrat Pada Performa Atlet. (2021).
Mahadi, R. et al. Immunomodulatory and Antioxidant Activity of Green Grass Jelly Leaf Extract (Cyclea Barbata Miers.) In Vitro. J. Trop. Biodivers. Biotechnol. 3, 73 (2018).
Jamshidi-Kia, F. et al. Battle between plants as antioxidants with free radicals in human body. J. Herbmed Pharmacol. 9, 191–199 (2020).
Obeagu, E. I., Ubosi, N. I. & Uzoma, G. Antioxidant Supplementation in Pregnancy: Effects on Maternal and Infant Health. Int. J. Adv. Multidiscip. Res 10, 60–70 (2023).
Farias, P. M. et al. Minerals in pregnancy and their impact on child growth and development. Molecules 25, 5630 (2020).
Manta-Vogli, P. D., Schulpis, K. H., Dotsikas, Y. & Loukas, Y. L. The significant role of amino acids during pregnancy: nutritional support. J. Matern. Neonatal Med. 33, 334–340 (2020).
Reddy, Vs., Palika, R., Ismail, A., Pullakhandam, R. & Reddy, Gb. Nutrigenomics: Opportunities & challenges for public health nutrition. Indian J. Med. Res. 148, 632 (2018).
Laurus, G., Fatimah, S. N. & Gurnida, D. A. Pattern of Energi and Protein Intake among Stunted Children Aged 3–5 Years in Jatinangor. Althea Med. J. 3, 364–370 (2016).
Kasolo, J. N., Bimenya, G. S., Ojok, L., Ochieng, J. & Ogwal-Okeng, J. Phytochemicals and uses of Moringa Oleifera leaves in Ugandan rural communities. J. Med. Plants Res. 4, 753–757 (2010).
Putra, A. I. Y. D., Setiawan, N. B. W., Sanjiwani, M. I. D., Wahyuniari, I. A. I. & Indrayani, A. W. Nutrigenomic and biomolecular aspect of moringa Oleifera leaf powder as supplementation for stunting children. J. Trop. Biodivers. Biotechnol. 6, 1–15 (2021).
Leone, A. et al. Cultivation, Genetic, Ethnopharmacology, Phytochemistry and Pharmacology of Moringa Oleifera Leaves: An Overview. Int. J. Mol. Sci. 16, 12791–12835 (2015).
Susanto, H., Hernowati, T. E. & Indra, M. R. Efficacy of Moringa Oleifera Leaf Powder as Nutrigenomic Therapy Against Malnutrition and Metabolic Perturbation Related Diseases: a Preliminary Study of Madura Islands Variety. in Proceedings of the 1st International Conference in One Health (ICOH 2017) (Atlantis Press, Paris, France, 2018). doi:10.2991/icoh-17.2018.53.
Dallio, M. et al. Nutrigenomics and Nutrigenetics in Metabolic- (Dysfunction) Associated Fatty Liver Disease: Novel Insights and Future Perspectives. Nutrients 13, 1679 (2021).
Huang, W.-L., Tung, C.-W., Liaw, C., Huang, H.-L. & Ho, S.-Y. Rule-Based Knowledge Acquisition Method for Promoter Prediction in Human and Drosophila Species. Sci. World J. 2014, 1–14 (2014).
Ma, Z. F., Ahmad, J., Zhang, H., Khan, I. & Muhammad, S. Evaluation of phytochemical and medicinal properties of Moringa (Moringa Oleifera) as a potential functional food. South African J. Bot. 129, 40–46 (2020).
Rodríguez-Cruz, M. & Serna, D. S. Nutrigenomics of ω-3 fatty acids: Regulators of the master transcription factors. Nutrition 41, 90–96 (2017).
Copyright (c) 2024 Amerta Nutrition
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
AMERTA NUTR by Unair is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
1. The journal allows the author to hold the copyright of the article without restrictions.
2. The journal allows the author(s) to retain publishing rights without restrictions
3. The legal formal aspect of journal publication accessibility refers to Creative Commons Attribution Share-Alike (CC BY-SA).
4. The Creative Commons Attribution Share-Alike (CC BY-SA) license allows re-distribution and re-use of a licensed work on the conditions that the creator is appropriately credited and that any derivative work is made available under "the same, similar or a compatible license”. Other than the conditions mentioned above, the editorial board is not responsible for copyright violation.
