The Effects of Cholecalciferol 1000 IU Supplementation on Handgrip Strength in Elderly with Vitamin D Deficiency
Pengaruh Cholecalciferol 1000 IU pada Kekuatan Genggam Tangan Lansia dengan Defisiensi Vitamin D
Downloads
Backgrounds: Vitamin D regulates muscle function by binding to vitamin D receptors (VDR) via genomic signaling pathways. The biologically active form of vitamin D (1,25-(OH)D) affects muscles by modulation of gene transcription and protein kinase signaling pathways that support proliferation and muscle growth. Aging will result in the interaction of vitamin D and VDR, affecting the regulation of muscle calcium channels, followed by a decrease in the stimulation of muscle contractions. Decreased synthesis and low vitamin D intake also affect serum level 25(OH)D. Maintaining vitamin D status in the elderly with vitamin D deficiency is expected to inhibit the decline in muscle strength and dysfunction.
Objectives: Determining the effect of giving cholecalciferol on handgrip strength.
Methods: An experimental study with randomized controlled trial (RCT) enrolled 54 elderly divided into treatment and control groups. The treatment group received cholecalciferol 1000 IU/day, and the control group received a placebo for 12 weeks. Both groups were examined for serum 25(OH) levels before and after treatment.
Results: Most samples in both groups (79.62%) showed vitamin D deficiency. There was an effect of 1000 IU cholecalciferol supplementation on serum 25(OH)D levels with a mean change of 3.8 (p<0.001), while the grip strength showed insignificant results with a mean change of 0.5 (p=0.748). No significant relationship existed between serum 25(OH)D level changes and hand grip strength (r=0.02; p=0.87).
Conclusions: Cholecalciferol supplementation of 1000 IU/day for 12 weeks increased serum vitamin D levels but did not increase grip strength.
Ministry of Health of Indonesia. Profil Kesehatan Indonesia 2018. (Badan Penelitian dan Pengembangan Kesehatan Kementrian RI, 2019).
Mailasari, I. et al. Demografi. Statistik Penduduk Lanjut Usia 2019 11–16 (Badan Pusat Statistik, 2019).
Girgis, C. M., Clifton-Bligh, R. J., Turner, N., Lau, S. L. & Gunton, J. E. Effects of Vitamin D in Skeletal Muscle: Falls, Strength, Athletic Performance and Insulin Sensitivity. Clinical Endocrinology (2014). doi:10.1111/cen.12368
Setiati, S. Geriatric Medicine, Sarkopenia, Frailty, dan Kualitas Hidup Pasien Usia Lanjut: Tantangan Masa Depan Pendidikan, Penelitian dan Pelayanan Kedokteran di Indonesia. eJournal Kedokt. Indones. 1 (2014). doi:10.23886/ejki.1.3008.
Remelli, F., Vitali, A., Zurlo, A. & Volpato, S. Vitamin D Deficiency and Sarcopenia in Older Persons. Nutrients. 11 (2019). doi:10.3390/nu11122861
Haslam, A. et al. Vitamin D Status is Associated with Grip Strength in Centenarians. J. Nutr. Gerontol. Geriatr. 33 (2014). doi:10.1080/21551197.2013.867825
Wintermeyer, E. et al. Crucial Role of Vitamin D in the Musculoskeletal System. 25, (2016).
Da Silva, P. Z. & Schneider, R. H. Muscle Strength and Muscle Mass in Elderly Women After Cholecalciferol Supplementation in Southern Brazil. PAJAR - Pan Am. J. Aging Res. 7, 32016 (2019).
Mak, J. An Evidence-Based Review of Efficacy and Safety of Dietary, Natural Supplements and Sunlight in Vitamin D Deficiency. in Vitamin D Deficiency 1–8 (IntechOpen, 2019). doi:http://dx.doi.org/10.5772/intechopen.89598
Bouillon, R. Comparative Analysis of Nutritional Guidelines for Vitamin D. Nat. Rev. Endocrinol. 13, 466–479 (2017).
Shenkin, A. & Thibault, R. Vitamins. in Basics Clinical Nutrition (ed. Sobotka, L.) 130 (GALEN, 2019).
Suryadinata, R. V. & Lorensia, A. Frekuensi Asupan Makanan, Pengetahuan Vitamin D dan Obesitas Pada Kelompok Usia Lanjut. Amerta Nutr. 43–48 (2020). doi:10.20473/amnt
Suryadinata, R. V., Lorensia, A. & Tangkilisan, E. C. Effect of Physical Activity and Vitamin D Status on Geriatrics Obesity. Glob. Med. Heal. Commun. 5 (2019). doi:10.29313/gmhc.v7i1.2916
Girgis, C. M., Clifton-bligh, R. J., Hamrick, M. W., Holick, M. F. & Gunton, J. E. The Roles of Vitamin D in Skeletal Muscle : Form , Function , and Metabolism The Roles of Vitamin D in Skeletal Muscle : Form , Function , and Metabolism. 34 (2012). doi:10.1210/er.2012-1012
Alqahtani, B., Alenazi, A., Alshehri, M., Alqahtani, M. & Elnaggar, R. Reference Values and Associated Factors of Hand Grip Strength in Elderly Saudi Population: A Cross-Sectional Study. BMC Geriatr. 19, 4–9 (2019).
RaÄić, M., Pavlović, J. & Ivković, N. Handgrip Strength Cut-Off Values for the Undernutrition Risk Screening among Elderly Men and Women in Bosnia and Herzegovina. J. Aging Res. 2019, (2019).
Eckman, M., Gigliotti, C., Sutermaster, S. & Mehta, K. Get a Grip! Handgrip Strength as a Health Screening Tool. Proc. 4th IEEE Glob. Humanit. Technol. Conf. GHTC 2014 242–248 (2014). doi:10.1109/GHTC.2014.6970288
Cavalcante, R. et al. The Effects of Intermittent Vitamin D3 Supplementation on Muscle Strength and Metabolic Parameters in Postmenopausal Women with Type 2 Diabetes: A Randomized Controlled Study. Ther. Adv. Endocrinol. Metab. 6 (2015). doi:10.1177/2042018815578998
El Hajj, C., Fares, S., Chardigny, J. M., Boirie, Y. & Walrand, S. Vitamin D Supplementation and Muscle Strength in Pre-Sarcopenic Elderly Lebanese People: A Randomized Controlled Trial. Arch. Osteoporos. 14, (2019).
Bolland, M. J., Grey, A. & Avenell, A. Effects of Vitamin D Supplementation on Musculoskeletal Health: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis. Lancet Diabetes Endocrinol. 6 (2018). doi:10.1016/S2213-8587(18)30265-1
Chareles S, A. H. Vitamin D Deficiency, Metabolism and Routine Measurement of its Metabolites [25(OH)D2 and 25(OH)D3]. J. Chromatogr. Sep. Tech. 6 (2015). doi:10.4172/2157-7064.1000276
Amrein, K. et al. Vitamin D Deficiency 2.0: An Update on the Current Status Worldwide. European Journal of Clinical Nutrition 74 (2020). doi:10.1038/s41430-020-0558-y
Ministry of Health of Indonesia. Badan Penelitian dan Pengembangan. Hasil Utama Riset Kesehatan Dasar. Kementrian Kesehat. Republik Indones. (2018). doi:1 Desember 2013
Chan, C. Y., Mohamed, N., Ima-Nirwana, S. & Chin, K. Y. Attitude of Asians to Calcium and Vitamin D Rich Foods and Supplements: A Systematic Review. Sains Malaysiana 48 (2018). doi:10.17576/jsm-2018-4708-19
Public Health England. Vitamin D and Health 2016. Sci. Advis. Comm. Nutr. 56–116 (2016). doi:10.1007/s00198-015-3440-3
Vanlint, S. Vitamin D and Obesity. Nutrients 5, 949–956 (2013).
World Health Organization Regional South East Asia. Health Situation and Trend Assessment Elderly Population. (2019). Available at: www.searo.who.int/entity/health_situation_trends/data/chi/elderly- population/en/.
Montenegro, K. R., Cruzat, V., Carlessi, R. & Newsholme, P. Mechanisms of Vitamin D Action in Skeletal Muscle. Nutr. Res. Rev. 25, 1–13 (2019).
Pirotta, S., Kidgell, D. J. & Daly, R. M. Effects of Vitamin D Supplementation on Neuroplasticity in Older Adults: A Double-Blinded, Placebo-Controlled Randomised Trial. Osteoporos. Int. 26 (2015). doi:10.1007/s00198-014-2855-6
Ganji, V., Martineau, B. & Van Fleit, W. E. Association of Serum Vitamin D Concentrations with Dietary Patterns in Children and Adolescents. Nutr. J. 17 (2018). doi:10.1186/s12937-018-0365-7
Copyright (c) 2023 Amerta Nutrition
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
AMERTA NUTR by Unair is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
1. The journal allows the author to hold the copyright of the article without restrictions.
2. The journal allows the author(s) to retain publishing rights without restrictions
3. The legal formal aspect of journal publication accessibility refers to Creative Commons Attribution Share-Alike (CC BY-SA).
4. The Creative Commons Attribution Share-Alike (CC BY-SA) license allows re-distribution and re-use of a licensed work on the conditions that the creator is appropriately credited and that any derivative work is made available under "the same, similar or a compatible license”. Other than the conditions mentioned above, the editorial board is not responsible for copyright violation.
