Moringa oleifera, Cyclea barbata, Centella asiatica Leaves Extract Intervention Ability to Improve Fetus Development and Blood Protein Levels in Malnutrition Pregnant Model Mice
Background. Pregnant women with chronic low energy conditions are at risk of having low birth weight babies and being born prematurely (stunted). Purpose. The research objective was to analyze leaf extract of Cyclea barbata , Centella asiatica and Moringa oleifera on fetal development and blood protein levels to prevent stunting. Methods: This type of research was an experimental laboratory, using 25 Mus musculus Balb/C, females, and adults as pregnant model animals with malnutrition, divided into 5 groups, namely pre-test, positive control, negative control, placebo, and test group. The negative control group and the treatment group got Cyclea barbata, Centella asiatica and Moringa oleifera leaf extracts with the formula 1:1:1 during pregnancy. Results: In the group of pregnant mice without malnutrition that received a mixture of leaf extracts of Cyclea barbata, Moringa oleifera and Centella asiatica, it turned out to have fetuses with an average body length of 9.7 % higher and 7.4% heavier than the group of pregnant mice with chronic lack of energy. Conclusion : The administration of Cyclea barbata, Centella asiatica and Moringa oleifera leaf extracts has a positive effect on fetal development and blood protein levels but less effective if given to pregnant women with chronic lack of energy but more effective as stunting prevention if given in normal pregnancy (not in conditions of chronic lack of energy)
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