Hubungan Asupan dan Kadar Serum β-karoten, Aktivitas SOD, TNF-α dan 8-isoprostan Serum dengan Ukuran Tumor Payudara
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Latar Belakang: Kanker payudara dapat disebabkan oleh berkembangnya Reactive Oxygen Species (ROS) di dalam sel yang memicu stres oksidatif dan oksidasi pada DNA. DNA akan kehilangan kemampuannya untuk memperbaiki diri dan terjadi mutasi. Mutasi dapat menyebabkan pertumbuhan dan perkembangan sel tumor. Asupan antioksidan seperti β-karoten pada penderita tumor dimungkinkan dapat menurunkan stres oksidatif dan risiko berkembangnya kanker.
Tujuan: Penelitian ini bertujuan untuk menganalisis hubungan asupan dan kadar serum β-karoten, aktivitas SOD, TNF-α dan 8-isoprostan serum dengan ukuran tumor payudara.
Metode: Penelitian ini menggunakan desain cross-sectional. Data yang digunakan adalah data baseline dari penelitian utama yang diambil pada bulan November-Desember 2018. Sebanyak 15 orang wanita yang terindikasi tumor payudara dan memenuhi kriteria inklusi serta eksklusi diikutsertakan dalam penelitian ini. Data dianalisis menggunakan uji korelasi Pearson dan spearman.
Hasil: Usia subjek berkisar antara 22-52 tahun dengan rata-rata usia 36 tahun. Hasil penelitian menunjukkan asupan β-karoten per hari masih kurang. Terdapat hubungan antara asupan β-karoten dengan aktivitas SOD (p=0,025; r=0,408) dan aktivitas SOD dengan ukuran tumor payudara (p=0,018; r=-0,430). Hal ini menunjukkan bahwa terdapat hubungan tidak langsung antara asupan β-karoten dengan ukuran tumor payudara. Kadar serum β-karoten, TNF-α dan 8-isoprostan serum tidak berhubungan signifikan dengan ukuran tumor payudara (p=0,107; r=-0,430 | p=0.061; r=0,347 | p= 0,217; r=0,232).
Kesimpulan: Terdapat hubungan antara asupan β-karoten dengan aktivitas SOD dan aktivitas SOD dengan ukuran tumor payudara.[Globocan] The Global Cancer Observatory. Cancer fact sheet. https://gco.iarc.fr/today/data/factsheets/cancers/39-All-cancers-fact-sheet.pdf (2019).
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